Evidence map›Paper›PMID 30116165›Full record

ArticleContrast media & molecular imaging2018

Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using

Yi-Hsiu Chung, Kuan-Ying Lu, Shao-Chieh Chiu, Chi-Jen Lo, Li-Man Hung, Jiung-Pang Huang, Mei-Ling Cheng, Chao-Hung Wang, Cheng-Kun Tsai, Yu-Chun Lin and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. The role of (Diagnostic and interventional radiology (Ankara, Turkey) · 2023
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yi-Hsiu ChungCenter for Advanced Molecular Imaging and Translation (CAMIT), Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Kuan-Ying LuDepartment of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Shao-Chieh ChiuCenter for Advanced Molecular Imaging and Translation (CAMIT), Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chi-Jen LoMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Li-Man HungDepartment and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jiung-Pang HuangDepartment and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Mei-Ling ChengClinical Metabolomics Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chao-Hung WangHeart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan.ORCID 0000-0001-5468-4354
Cheng-Kun TsaiClinical Metabolomics Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yu-Chun LinDepartment of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0001-6841-5366
Shang-Hung ChangDepartment and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Gigin LinDepartment of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0001-7246-1058
Chang Gung University · TWChang Gung Memorial Hospital · TWKeelung Chang Gung Memorial Hospital · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: High-fat diet (HFD) induces systemic insulin resistance leading to myocardial dysfunction. We aim to characterize the early adaptations of myocardial glucose utility to HFD-induced insulin resistance. Methods: Male Sprague-Dawley rats were assigned into two groups, fed a regular chow diet or HFD ad libitum for 10 weeks. We used Results: As compared with controls, HFD rats had a higher ejection fraction and a smaller left ventricular end-systolic volume ( Conclusions: HFD-induced IR associated with increased glucose utility undergoing oxidative phosphorylation via the TCA cycle in the myocardium is supported by overexpression of glucose transporter, acetyl-CoA synthase. Noninvasive imaging biomarker has potentials in detecting the metabolic perturbations prior to the decline of the left ventricular function.

Indexed as

Insulin ResistanceMagnetic Resonance SpectroscopyPositron-Emission TomographyAnimalsBiomarkersCarbon IsotopesDiet, High-FatDisease Models, AnimalFluorodeoxyglucose F18GlucoseGlucose Transporter Type 4HemodynamicsMaleMicrotubule-Associated ProteinsMyocardiumObesityAnxa3 protein, ratBiomarkersCarbon-13Carbon IsotopesFluorodeoxyglucose F18GlucoseGlucose Transporter Type 4Microtubule-Associated ProteinsPoly(ADP-ribose) PolymerasesRNA, Messenger

Identifiers

PMID30116165
PMCPMC6079607
OpenAlexW2884680322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.