Evidence map›Paper›PMID 30115989›Full record

ArticleScientific reports2018

Primary prevention of atherosclerosis by pretreatment of low-density lipoprotein receptor knockout mice with sesame oil and its aqueous components.

Chandrakala Aluganti Narasimhulu, Kathryn Young Burge, Mitsushita Doomra, Aladdin Riad, Sampath Parthasarathy

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chandrakala Aluganti NarasimhuluBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, USA.
Kathryn Young BurgeBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, USA.
Mitsushita DoomraBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, USA.
Aladdin RiadBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, USA.
Sampath ParthasarathyBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, USA. spartha@ucf.edu.
University of Central Florida · US

Funding

Non-pharmacological control of atherosclerosisR01AT004106 · NCCIH · UNIVERSITY OF CENTRAL FLORIDA · PI PARTHASARATHY, SAMPATH · 2010 to 2014
$1.9M
NCCIH NIH HHS R01 AT004106
6 · The paper itself

Abstract

Pharmacological intervention using statins and PCSK9 inhibitors have become first-line therapy in the prevention of hypercholesterolemia and atherosclerosis. Currently, no agent is available for the primary prevention of atherosclerosis. However, there is an emerging hypothesis that atherosclerosis could be driven by inflammation. In this study, we tested whether pretreatment with an aqueous extract from sesame oil (SOAE), which showed potent anti-inflammatory properties without hypocholesterolemic actions, would prevent subsequent atherosclerosis development in a mouse model. RAW 264.7 macrophages and female low-density lipoprotein receptor knockout (LDLR

Indexed as

AnimalsAtherosclerosisDisease ProgressionLipoproteins, LDLMiceMice, KnockoutReceptors, LDLSesame OilTranscriptomeWaterLipoproteins, LDLoxidized low density lipoproteinReceptors, LDLSesame OilWater

Identifiers

PMID30115989
PMCPMC6095901
OpenAlexW2886482437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.