ArticleScientific reports2018
A thyroid hormone regulated asymmetric responsive centre is correlated with eye migration during flatfish metamorphosis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Environmental tuning of thyroid hormone signaling drives developmental plasticity.Science advances · 2026Article
- The human THRB thyroid hormone receptor gene and the puzzle of retinal disease phenotypes.Developmental biology · 2026Review
- Global Change Asymmetrically Rewires Ecosystems.Ecology letters · 2025Review
- Differentiation versus dysfunction: thyroid hormone, deiodinases and retinal photoreceptors.European thyroid journal · 2025Review
- The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (eLife · 2024Article
- Phylogenomic and comparative genomic analyses support a single evolutionary origin of flatfish asymmetry.Nature genetics · 2024Article
- Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis.Communications biology · 2024Article
- Review
- Thyroid hormone shapes craniofacial bones during postembryonic zebrafish development.Evolution & development · 2022Article
- Brains in Metamorphosis: Temporal Transcriptome Dynamics in Hatchery-Reared Flatfishes.Biology · 2021Article
- Larval metamorphosis is inhibited by methimazole and propylthiouracil that reveals possible hormonal action in the mussel Mytilus coruscus.Scientific reports · 2021Article
- A star is born again: Methods for larval rearing of an emerging model organism, the False clownfish Amphiprion ocellaris.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Article
- TISSUE CLEARING.Nature reviews. Methods primers · 2021Article
- An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae.Scientific reports · 2020Article
- New Insights on Vitamin K Metabolism in Senegalese sole (International journal of molecular sciences · 2020Article
- Role of thyroid hormones in craniofacial development.Nature reviews. Endocrinology · 2020Review
- The Role of the Thyroid Axis in Fish.Frontiers in endocrinology · 2020Review
- Thyroid hormone coordinates developmental trajectories but does not underlie developmental truncation in danionins.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Genomic and phylogenetic analysis of choriolysins, and biological activity of hatching liquid in the flatfish Senegalese sole.PloS one · 2019Article
- Teleost Metamorphosis: The Role of Thyroid Hormone.Frontiers in endocrinology · 2019Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Flatfish metamorphosis is a unique post-embryonic developmental event in which thyroid hormones (THs) drive the development of symmetric pelagic larva into asymmetric benthic juveniles. One of the eyes migrates to join the other eye on the opposite side of the head. Developmental mechanisms at the basis of the acquisition of flatfish anatomical asymmetry remain an open question. Here we demonstrate that an TH responsive asymmetric centre, determined by deiodinase 2 expression, ventrally juxtaposed to the migrating eye in sole (Solea senegalensis) correlates with asymmetric cranial ossification that in turn drives eye migration. Besides skin pigmentation that is asymmetric between dorsal and ventral sides, only the most anterior head region delimited by the eyes becomes asymmetric whereas the remainder of the head and organs therein stay symmetric. Sub-ocular ossification is common to all flatfish analysed to date, so we propose that this newly discovered mechanism is universal and is associated with eye migration in all flatfish.
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Registered trials
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