Evidence map›Paper›PMID 30115919›Full record

ArticleNature communications2018

Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators.

Eric Sage, Marc Sansa, Shawn Fostner, Martial Defoort, Marc Gély, Akshay K Naik, Robert Morel, Laurent Duraffourg, Michael L Roukes, Thomas Alava and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Label-Free Anti-Brownian Trapping of Single Nanoparticles in Solution.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eric SageUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Marc SansaUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Shawn FostnerUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Martial DefoortUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Marc GélyUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Akshay K NaikCentre for Nano Science and Engineering, Indian Institute of Science, Bangalore, 560012, India.
Robert MorelUniv. Grenoble Alpes, CEA, CNRS, Grenoble INP, INAC-Spintec, 38000, Grenoble, France.
Laurent DuraffourgUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Michael L RoukesKavli Nanoscience Institute and Departments of Physics, Applied Physics, and Bioengineering, California Institute of Technology, MC 149-33, Pasadena, CA, 91125, USA.
Thomas AlavaUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Guillaume JourdanUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Eric ColinetUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France.
Christophe MasselonUniversité Grenoble-Alpes, 38000, Grenoble, France.
Ariel BrenacUniv. Grenoble Alpes, CEA, CNRS, Grenoble INP, INAC-Spintec, 38000, Grenoble, France.
Sébastien HentzUniv. Grenoble Alpes, CEA, LETI, 38000, Grenoble, France. sebastien.hentz@cea.fr.ORCID http://orcid.org/0000-0003-0479-9027

Funding

EC | European Research Council (ERC) 616251
6 · The paper itself

Abstract

One of the main challenges to overcome to perform nanomechanical mass spectrometry analysis in a practical time frame stems from the size mismatch between the analyte beam and the small nanomechanical detector area. We report here the demonstration of mass spectrometry with arrays of 20 multiplexed nanomechanical resonators; each resonator is designed with a distinct resonance frequency which becomes its individual address. Mass spectra of metallic aggregates in the MDa range are acquired with more than one order of magnitude improvement in analysis time compared to individual resonators. A 20 NEMS array is probed in 150 ms with the same mass limit of detection as a single resonator. Spectra acquired with a conventional time-of-flight mass spectrometer in the same system show excellent agreement. We also demonstrate how mass spectrometry imaging at the single-particle level becomes possible by mapping a 4-cm-particle beam in the MDa range and above.

Identifiers

PMID30115919
PMCPMC6095856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.