Evidence map›Paper›PMID 30115809›Full record

ArticleScience (New York, N.Y.)2018

Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins.

Ethan J Greenblatt, Allan C Spradling

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 152 citations in OpenAlex.

  1. Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. FMR1 KH0-KH1 domains coordinate mExperimental cell research · 2025
    Article
  6. eNeuro · 2025
    Article
  7. Science advances · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Decoding Nucleotide Repeat Expansion Diseases: Novel Insights fromInternational journal of molecular sciences · 2024
    Review
  13. Review
  14. The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ethan J GreenblattHoward Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA.ORCID 0000-0002-3805-0113
Allan C SpradlingHoward Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA. spradling@ciwemb.edu.ORCID 0000-0002-5251-1801
Howard Hughes Medical Institute · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Mutations in the fragile X mental retardation 1 gene (

Indexed as

Protein BiosynthesisAnimalsAutistic DisorderDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianFragile X Messenger Ribonucleoprotein 1Gene Knockdown TechniquesHumansNervous System MalformationsOocytesRNA, MessengerDrosophila ProteinsFMR1 protein, DrosophilaFragile X Messenger Ribonucleoprotein 1RNA, Messenger

Identifiers

PMID30115809
PMCPMC6905618
OpenAlexW2885103884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.