ReviewLearning & memory (Cold Spring Harbor, N.Y.)2018
Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.
Review in Learning & memory (Cold Spring Harbor, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Substance-related intrusive memories in cocaine use disorder are different from but associated with craving.Addiction (Abingdon, England) · 2026Article
- New Approaches for Alcohol Use Disorder Treatment via Memory Retrieval and Reconsolidation Manipulations.Current topics in behavioral neurosciences · 2025Review
- Perineuronal Nets in the Rat Medial Prefrontal Cortex Alter Hippocampal-Prefrontal Oscillations and Reshape Cocaine Self-Administration Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Interfering with reconsolidation by rimonabant results in blockade of heroin-associated memory.Frontiers in pharmacology · 2024Article
- Influence of reconsolidation in maintenance of cocaine-associated contextual memories formed during adolescence or adulthood.Scientific reports · 2023Article
- Nociceptor activity induces nonionotropic NMDA receptor signaling to enable spinal reconsolidation and reverse pathological pain.Science advances · 2023Article
- Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse.Translational psychiatry · 2023Article
- Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- A critical perspective on updating drug memories through the integration of memory editing and brain stimulation.Frontiers in psychiatry · 2023Review
- Reward, motivation and brain imaging in human healthy participants - A narrative review.Frontiers in behavioral neuroscience · 2023Review
- Optogenetic inhibition of the dorsal hippocampus CA3 region during early-stage cocaine-memory reconsolidation disrupts subsequent context-induced cocaine seeking in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Temporal prediction error triggers amygdala-dependent memory updating in appetitive operant conditioning in rats.Frontiers in behavioral neuroscience · 2022Article
- Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling.Frontiers in pharmacology · 2022Article
- Targeting the Reconsolidation of Licit Drug Memories to Prevent Relapse: Focus on Alcohol and Nicotine.International journal of molecular sciences · 2021Review
- Memory Retrieval-Extinction Combined With Virtual Reality Reducing Drug Craving for Methamphetamine: Study Protocol for a Randomized Controlled Trial.Frontiers in psychiatry · 2020Article
- Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches.Frontiers in behavioral neuroscience · 2019Article
- Reactivation of the Unconditioned Stimulus Inhibits the Return of Fear Independent of Cortisol.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is thought to be driven by maladaptive learning processes which store and maintain associative memory, linking drug highs with cues and actions in the environment. These memories can encode Pavlovian associations which link predictive stimuli (e.g., people, places, and paraphernalia) with a hedonic drug high, as well as instrumental learning about the actions required to obtain drug-associated incentives. Learned memories are not permanent however, and much recent interest has been generated in exploiting the process of reconsolidation to erase or significantly weaken maladaptive memories to treat several mental health disorders, including addictions. Normally reconsolidation serves to update and maintain the adaptive relevance of memories, however administration of amnestic agents within the critical "reconsolidation window" can weaken or even erase maladaptive memories. Here we discuss recent advances in the field, including ongoing efforts to translate preclinical reconsolidation research in animal models into clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.