ReviewLearning & memory (Cold Spring Harbor, N.Y.)2018
The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse.
Review in Learning & memory (Cold Spring Harbor, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.Current neuropharmacology · 2025Pooled it
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- Clustering of substance use and its association with adolescents' health and well-being: evidence from the Health Behaviour in School-aged Children (HBSC) Luxembourg study.BMC public health · 2026Article
- Acute recreational drug and ethanol poisoning among adolescents: An observational study from Oslo, Norway 2014-2023.Toxicology reports · 2025Article
- Potential roles for microglia in drug addiction: Adolescent neurodevelopment and beyond.Journal of neuroimmunology · 2025Review
- Long-term effects of adolescent versus adult nicotine self-administration on cholinergic modulation of dopamine in the nucleus accumbens core.Drug and alcohol dependence · 2025Article
- Narrative Review: Revised Principles and Practice Recommendations for Adolescent Substance Use Treatment and Policy.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Review
- Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes.World journal of diabetes · 2024Article
- Alcohol Consumption During Adolescence Alters the Cognitive Function in Adult Male Mice by Persistently Increasing Levels of DUSP6.Molecular neurobiology · 2024Article
- Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Fine-Regional Role of the Claustrum in Anxiety and Higher Sensitivity to Cocaine in Adolescent Cocaine-Exposed Male Mice during Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
- Immersive virtual plus-maze to examine behavior and psychophysiological-related variables in young people with problematic alcohol and cannabis consumption.Neurobiology of stress · 2023Article
- Earthquake exposure during adolescence and later-life depressive symptoms: A national cross-sectional survey.SSM - population health · 2023Article
- Unpacking disparities in substance-related outcomes among racial, ethnic, sexual, and gender minoritized groups during adolescence and emerging adulthood.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Review
- Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.bioRxiv : the preprint server for biology · 2023Article
- Adolescent alcohol and nicotine exposure alters the adult response to alcohol use.Advances in drug and alcohol research · 2023Review
- Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment.Frontiers in behavioral neuroscience · 2023Article
- Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies.Brain research bulletin · 2022Review
- Dual Use of Nicotine and Cannabis Through Vaping Among Adolescents.American journal of preventive medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During adolescence, the brain continues to undergo vital developmental processes. In turn, complex behavioral and cognitive skills emerge. Unfortunately, neurobiological development during adolescence can be influenced by environmental factors such as drug exposure. Engaging in drug use during adolescence has been a long-standing health concern, especially how it predicts or relates to drug using behavior later in life. However, recent findings suggest that other behavioral domains, such as learning and memory, are also vulnerable to adolescent drug use. Moreover, it is becoming increasingly apparent that deficits in learning and memory following adolescent drug use endure into adulthood, well after drug exposure has subsided. Although persistent effects suggest an interaction between drug exposure and ongoing development during adolescence, the exact acute and long-term consequences of adolescent drug exposure on substrates of learning and memory are not fully understood. Thus, this review will summarize human and animal findings on the enduring cognitive deficits due to adolescent drug exposure. Moreover, due to the fact that adolescents are more likely to consume drugs of abuse legally available to adults, this review will focus on alcohol, nicotine, and marijuana. Further, given the critical role of the frontal cortex and hippocampus in various learning and memory domains, the impact adolescent use of the previous listed drugs on the neurobiology within these regions will also be discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.