ReviewLearning & memory (Cold Spring Harbor, N.Y.)2018
The hot 'n' cold of cue-induced drug relapse.
Review in Learning & memory (Cold Spring Harbor, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism.Nature communications · 2026Article
- Article
- Genetic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.Genes, brain, and behavior · 2025Article
- Article
- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.bioRxiv : the preprint server for biology · 2024Article
- Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats.Scientific reports · 2024Article
- Individual differences in late positive potential amplitude and theta power predict cue-induced eating.Addiction neuroscience · 2023Article
- Article
- Pharmacological activation of the amygdala, but not single prolonged footshock-induced acute stress, interferes with cue-induced motivation toward food rewards in rats.Frontiers in behavioral neuroscience · 2023Article
- Comment on Pohorala et al.: Sign-tracking as a predictor of addiction vulnerability.Psychopharmacology · 2021Article
- Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats.Scientific reports · 2021Article
- Nicotine Enhances Goal-Tracking in Ethanol and Food Pavlovian Conditioned Approach Paradigms.Frontiers in neuroscience · 2021Article
- Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei.Frontiers in neuroscience · 2021Article
- Addiction vulnerability and the processing of significant cues: Sign-, but not goal-, tracker perceptual sensitivity relies on cue salience.Behavioral neuroscience · 2020Article
- The transition to cocaine addiction: the importance of pharmacokinetics for preclinical models.Psychopharmacology · 2019Article
- Basal forebrain chemogenetic inhibition disrupts the superior complex movement control of goal-tracking rats.Behavioral neuroscience · 2019Article
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Environmental cues associated with rewards can acquire motivational properties. However, there is considerable variation in the extent to which a reward cue gains motivational control over behavior, depending on the individual and the form of the cue. When a discrete cue is paired with food reward, it acquires greater control over motivated behavior in some rats (sign-trackers, STs) than others (goal-trackers, GTs) as indicated by the propensity to approach the cue, the willingness to work to obtain it, and its ability to reinstate reward-seeking behavior. Here, we review studies that employ this ST/GT animal model to investigate characteristics of individuals that are especially susceptible to reward cue-elicited behavior and the involvement of dopamine and acetylcholine neuromodulator systems in the susceptibility to cue-induced drug relapse. First, we discuss individual differences in the attribution of incentive salience to different forms of reward cues and the involvement of the mesolimbic dopamine system. We then discuss individual differences in cognitive/attentional control and the contributions of the cholinergic system in processing reward cues. It is suggested that in STs a propensity to attribute motivational properties to a drug cue is combined with poor attentional control in the face of these cues, making them particularly vulnerable to transition from casual/experimental patterns of drug use to addiction and to cue-induced relapse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.