ArticleThe Journal of experimental medicine2018
h
Open access · bronzeAbstract readCase Reports
In one paragraph
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Role of meningeal lymphatic vessels in brain homeostasis.Frontiers in immunology · 2025Pooled it
- Polymorphisms inAnimals : an open access journal from MDPI · 2026Article
- Etiological diagnosis of miscarriage by combining use of chromosomal microarray analysis and whole-exome sequencing.European journal of medical research · 2025Article
- Evidence of Involvement of the Calcitonin Gene-Related Peptide in Restless Legs Syndrome.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Meningeal lymphatic drainage: novel insights into central nervous system disease.Signal transduction and targeted therapy · 2025Review
- Fine mapping of candidate effector genes for heart rate.Human genetics · 2024Article
- A Splice Site Variant inAnimals : an open access journal from MDPI · 2024Article
- Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice.The Journal of clinical investigation · 2024Article
- Quantitative proteomics reveals CLR interactome in primary human cells.The Journal of biological chemistry · 2024Article
- Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models.The Journal of clinical investigation · 2024Article
- Investigation into the genetics of fetal congenital lymphatic anomalies.Prenatal diagnosis · 2023Article
- Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.Circulation research · 2023Review
- BiallelicJournal of medical genetics · 2023Article
- Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development.International journal of molecular sciences · 2022Article
- Role of Transcriptional and Epigenetic Regulation in Lymphatic Endothelial Cell Development.Cells · 2022Review
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia.Frontiers in cell and developmental biology · 2022Review
- Fetal nuchal edema and developmental anomalies caused by gene mutations in mice.Frontiers in cell and developmental biology · 2022Review
- Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target.Frontiers in endocrinology · 2021Article
- The Lymphatic Vasculature in the 21Cell · 2020Review
- Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay.The Journal of biological chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Duncan I MackieDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0001-5299-9475
Fuad Al MutairiDepartment of Pediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia almutairifu@ngha.med.sa.
Reema B DavisDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC.
Daniel O KecheleDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0001-5377-1392
Natalie R NielsenDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC.
Joshua C SnyderDepartment of Cell Biology, Duke University Medical Center, Durham, NC.
Marc G CaronDepartment of Cell Biology, Duke University Medical Center, Durham, NC.
Harvey J KlimanDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.ORCID 0000-0002-2151-7071
Jonathan S BergDepartment of Genetics, University of North Carolina, Chapel Hill, NC.
John SimmsSchool of Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, England, UK.
David R PoynerSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, England, UK.ORCID 0000-0003-1590-112X
Kathleen M CaronDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC Kathleen_caron@med.unc.edu.ORCID 0000-0002-7033-9232
University of North Carolina at Chapel Hill · USDuke Medical Center · USAston University · GBCoventry University · GBKing Saud bin Abdulaziz University for Health Sciences · SAYale University · US
Funding
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5MClinical Oncology Research Career Development ProgramK12CA100639 · NCI · DUKE UNIVERSITY · PI LYERLY, HERBERT KIM · 2004 to 2013
$8.0MScience PlanP30DA029925 · NIDA · DUKE UNIVERSITY · PI CARON, MARC G. · 2010 to 2018
$6.2MAdrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8MCardiac Lymphatics in Heart FailureR01HL129086 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2016 to 2023
$4.1MCauses and Consequences of Digestive Tract LymphangiectasiaR01DK099156 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2013 to 2016
$1.3MSupplemental Funds for K22 Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behaviorK22CA212058 · NCI · DUKE UNIVERSITY · PI SNYDER, JOSHUA CLAIR · 2017 to 2020
$622kNovel Interactions Between G protein coupled receptors and Receptor Activity Modifying Proteins and Their Control of Angiogenic CuesF32HL134279 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACKIE, DUNCAN IAN · 2016 to 2018
$174kAdrenomedullin affects Lymphatics and Immune Activation to Promote MetastasisF31CA174194 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KECHELE, DANIEL OLIVER · 2013 to 2014
$60kBiotechnology and Biological Sciences Research Council BB/M007529/1NCI NIH HHS F31 CA174194NCI NIH HHS K12 CA100639NCI NIH HHS K22 CA212058NHLBI NIH HHS F32 HL134279NHLBI NIH HHS R01 HL129086NICHD NIH HHS R01 HD060860NIDA NIH HHS P30 DA029925NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK099156
Abstract
We report the first case of nonimmune hydrops fetalis (NIHF) associated with a recessive, in-frame deletion of V205 in the G protein-coupled receptor, Calcitonin Receptor-Like Receptor (h
Indexed as
Amino Acid SequenceCalcitonin Receptor-Like ProteinCraniofacial AbnormalitiesHydrops FetalisLymphangiectasis, IntestinalLymphedemaMice, TransgenicSequence DeletionAnimalsDisease Models, AnimalFemaleHEK293 CellsHeterozygoteHomozygoteHumansMaleCalcitonin Receptor-Like ProteinCALCRL protein, humanCalcrl protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.