Evidence map›Paper›PMID 30115693›Full record

ArticleCancer research2018

IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.

Heather M Gibson, Brooke N McKnight, Agnes Malysa, Greg Dyson, Wendy N Wiesend, Claire E McCarthy, Joyce Reyes, Wei-Zen Wei, Nerissa T Viola-Villegas

Abstract read
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Granzyme B PET/CT predicts chemo-immunotherapy outcomes in microsatellite stable gastric cancers.European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Imaging the fate of CAR-T cellsFrontiers in immunology · 2026
    Review
  5. Review
  6. Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Approaches to Imaging Immune Activation Using PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Visualizing T-cell activation: PET imaging of CXCL9 as a window into the tumor immune response.American journal of nuclear medicine and molecular imaging · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Druggability of Targets for Diagnostic Radiopharmaceuticals.ACS pharmacology & translational science · 2023
    Review
  18. Immune checkpoint inhibition: a future guided by radiology.The British journal of radiology · 2023
    Review
  19. Advances in PET imaging of cancer.Nature reviews. Cancer · 2023
    Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Heather M Gibson *Department of Oncology, Karmanos Cancer Institute, Detroit, Michigan.
Brooke N McKnight *Department of Oncology, Karmanos Cancer Institute, Detroit, Michigan.
Agnes MalysaDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan.ORCID 0000-0002-4527-2347
Greg DysonDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan.
Wendy N WiesendDepartment of Anatomic Pathology, Beaumont Health System, Royal Oak, Michigan.
Claire E McCarthyDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan.
Joyce ReyesDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan.
Wei-Zen WeiDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan. villegan@karmanos.org weiw@karmanos.org.
Nerissa T Viola-VillegasDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan. villegan@karmanos.org weiw@karmanos.org.
The Barbara Ann Karmanos Cancer Institute · USBeaumont Health · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
TRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · NCI · WAYNE STATE UNIVERSITY · PI Larry H Matherly · 1985 to 2026
$5.3M
DEVELOPMENT OF ERBB2 BASED BREAST CANCER VACCINESR01CA076340 · NCI · WAYNE STATE UNIVERSITY · PI WEI, WEI-ZEN · 1998 to 2020
$5.2M
Delineating Functional Immunity via Image-Guided PETR37CA220482 · NCI · WAYNE STATE UNIVERSITY · PI GIBSON, HEATHER MARIE, VIOLA, NERISSA THERESE · 2018 to 2024
$3.9M
Delineating tumors with resistance to tyrosine kinase therapy via PET imagingR00CA181492 · NCI · WAYNE STATE UNIVERSITY · PI VIOLA, NERISSA THERESE · 2015 to 2017
$662k
NCI NIH HHS P30 CA022453NCI NIH HHS R00 CA181492NCI NIH HHS R01 CA076340NCI NIH HHS R37 CA220482
6 · The paper itself

Abstract

IFNγ is an attractive target for imaging active antitumor immunity due to its function in the T-cell signaling axis. Here, we test an IFNγ immuno-PET (immunoPET) probe for its capacity to identify adaptive immunotherapy response after HER2/neu vaccination in both spontaneous salivary and orthotopic neu

Indexed as

ImmunotherapyPositron-Emission TomographyAnimalsBinding, CompetitiveCD3 ComplexCD8-Positive T-LymphocytesCell Line, TumorCpG IslandsFemaleHeterozygoteInterferon-gammaLymphocyte ActivationLymphocytes, Tumor-InfiltratingMammary Neoplasms, AnimalMiceMice, Inbred BALB CCD3 ComplexInterferon-gammaPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorRadiopharmaceuticals

Identifiers

PMID30115693
PMCPMC6443251
OpenAlexW2893596384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.