Evidence map›Paper›PMID 30115614›Full record

ArticleThe European respiratory journal2018

Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities.

Sara C Auld, N Sarita Shah, Barun Mathema, Tyler S Brown, Nazir Ismail, Shaheed Vally Omar, James C M Brust, Kristin N Nelson, Salim Allana, Angela Campbell and 3 more

Abstract read
In one paragraph

Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Lancet regional health. Americas · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Multidrug-resistant tuberculosis.Nature reviews. Disease primers · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sara C AuldSchool of Medicine, Emory University, Atlanta, GA, USA.
N Sarita ShahRollins School of Public Health, Emory University, Atlanta, GA, USA.
Barun MathemaMailman School of Public Health, Columbia University, New York, NY, USA.
Tyler S BrownMailman School of Public Health, Columbia University, New York, NY, USA.
Nazir IsmailNational Institute for Communicable Diseases, Johannesburg, South Africa.
Shaheed Vally OmarNational Institute for Communicable Diseases, Johannesburg, South Africa.
James C M BrustAlbert Einstein College of Medicine, Bronx, NY, USA.
Kristin N NelsonRollins School of Public Health, Emory University, Atlanta, GA, USA.
Salim AllanaRollins School of Public Health, Emory University, Atlanta, GA, USA.
Angela CampbellRollins School of Public Health, Emory University, Atlanta, GA, USA.
Koleka MlisanaSchool of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Pravi MoodleyNational Health Laboratory Service, Durban, South Africa.
Neel R GandhiSchool of Medicine, Emory University, Atlanta, GA, USA.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HARRIS GOLDSTEIN · 2017 to 2026
$28.3M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Role of antigen-specific T cell responses in the control of TBU19AI111211 · NIAID · EMORY UNIVERSITY · PI RENGARAJAN, JYOTHI · 2014 to 2020
$20.1M
Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
The Emory Training Program in Lung HealthT32HL116271 · NHLBI · EMORY UNIVERSITY · PI BROWN, LOU ANN S, GUIDOT, DAVID MARSHALL · 2013 to 2022
$4.2M
Impact of HIV, Antiretroviral Therapy and TB Genotype on Survival in MDR TBR01AI087465 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2010 to 2014
$3.9M
The Role of Casual Contact and Migration in XDR TB Transmission in South Africa: a Geospatial, Genomic and Social Network StudyR01AI138646 · NIAID · EMORY UNIVERSITY · PI MLISANA, KOLEKA P, SHAH, NIPPIE SARITA · 2018 to 2022
$3.8M
Transmission of HIV-Associated XDR TB in Rural South AfricaR01AI089349 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2010 to 2014
$3.7M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
Impact of HIV infection on early responses to TB exposureK23AI134182 · NIAID · EMORY UNIVERSITY · PI AULD, SARA · 2018 to 2023
$972k
Integrated, Home-based Treatment for MDR TB and HIV in Rural South AfricaK23AI083088 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BRUST, JAMES C M · 2010 to 2014
$665k
NCATS NIH HHS UL1 TR001073NHLBI NIH HHS T32 HL116271NIAID NIH HHS K23 AI083088NIAID NIH HHS K23 AI134182NIAID NIH HHS K24 AI114444NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI051519NIAID NIH HHS P30 AI124414NIAID NIH HHS R01 AI087465NIAID NIH HHS R01 AI089349NIAID NIH HHS R01 AI138646NIAID NIH HHS U19 AI111211
6 · The paper itself

Abstract

Despite evidence that transmission is driving an extensively drug-resistant TB (XDR-TB) epidemic, our understanding of where and between whom transmission occurs is limited. We sought to determine whether there was genomic evidence of transmission between individuals without an epidemiologic connection.We conducted a prospective study of XDR-TB patients in KwaZulu-Natal, South Africa, during the 2011-2014 period. We collected sociodemographic and clinical data, and identified epidemiologic links based on person-to-person or hospital-based connections. We performed whole-genome sequencing (WGS) on the

Indexed as

AdultAntitubercular AgentsExtensively Drug-Resistant TuberculosisFemaleGenomicsHumansMaleMicrobial Sensitivity TestsMycobacterium tuberculosisPolymorphism, Single NucleotideProspective StudiesSouth AfricaWhole Genome SequencingAntitubercular Agents

Identifiers

PMID30115614
PMCPMC6195447

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.