ArticleEpilepsy & behavior : E&B2018
Negative effects of interictal spikes on theta rhythm in human temporal lobe epilepsy.
Article in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Theta Oscillations, Oculomotor Processing, and Neural Synchronization: A Review.Brain sciences · 2026Review
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Timing is everything: The effect of early-life seizures on developing neuronal circuits subserving spatial memory.Epilepsia open · 2025Review
- Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance.bioRxiv : the preprint server for biology · 2024Article
- Temporal intermittent rhythmic theta activity (TIRTA): A marker of epileptogenicity?eNeurologicalSci · 2022Article
- Theta waves, neural spikes and seizures can propagate by ephaptic coupling in vivo.Experimental neurology · 2022Article
- Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis.Sensors (Basel, Switzerland) · 2022Article
- The effect of interictal epileptic discharges and following spindles on motor sequence learning in epilepsy patients.Frontiers in neurology · 2022Article
- The Oscillatory Basis of Working Memory Function and Dysfunction in Epilepsy.Frontiers in human neuroscience · 2020Review
- Ripple While You Walk, and You May Get Lost: Pathological High-Frequency Activity Can Alter Spatial Navigation Circuits.Epilepsy currents · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Interictal spike is a biomarker of epilepsy that can occur frequently between seizures. Its potential effects on brain oscillations, especially on theta rhythm (4-8 Hz) that is related to a variety of cognitive processes, remain controversial. Using local field potentials recorded from patients with temporal lobe epilepsy (TLE), we investigated here the impact of spikes on theta rhythm immediately after spikes and during the prolonged periods (lasting 4-36 s) between adjacent spikes. Local field potentials (LFPs) were recorded in different epileptogenic areas including the anterior hippocampus (aH) and the entorhinal cortex (EC) as well as in the extended propagation pathway. We found that interictal spikes had a significant inhibitory effect on theta rhythm. Power of theta rhythm was reduced immediately after spikes, and the inhibitory effect on theta rhythm might sustain during the prolonged between-spike periods. The inhibitory effect was more severe when the epileptogenic areas involved both the aH and EC compared to that involved only a single structure. These observations suggest that interictal spikes have a significant negative impact on theta rhythm and may thus play a role in theta-related cognition changes in patients with TLE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.