ArticlePrimary care diabetes2018
Roles of insulin resistance and beta cell dysfunction in macrosomia among Chinese women with gestational diabetes mellitus.
Article in Primary care diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prevalence and risk factors for type 2 diabetes mellitus in women with gestational diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Association between insulin resistance trajectories and perinatal complications: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Adiponectin C1Q and Collagen Domain Containing rs266729, Cyclin-Dependent Kinase Inhibitor 2A and 2B rs10811661, and Signal Sequence Receptor Subunit 1 rs9505118 Polymorphisms and Their Association with Gestational Diabetes Mellitus: A Case-Control Study in a Romanian Population.International journal of molecular sciences · 2025Article
- History of large-for-gestational-age birth is independently associated with subsequent gestational diabetes in Chinese multiparous women: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Gestational diabetes mellitus in previous pregnancy associated with the risk of large for gestational age and macrosomia in the second pregnancy.Frontiers in endocrinology · 2025Article
- Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes.Nature medicine · 2024Article
- Refining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis.Communications medicine · 2023Article
- Placental RNA sequencing implicates IGFBP1 in insulin sensitivity during pregnancy and in gestational diabetes.Research square · 2023Article
- Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum.International journal of endocrinology · 2022Article
- Protective Effects of Astragaloside IV on Uric Acid-Induced PancreaticEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Associations between insulin resistance and adverse pregnancy outcomes in women with gestational diabetes mellitus: a retrospective study.BMC pregnancy and childbirth · 2021Article
- A Novel Review of Homocysteine and Pregnancy Complications.BioMed research international · 2021Review
- Article
- Expression of miR-409-5p in gestational diabetes mellitus and its relationship with insulin resistance.Experimental and therapeutic medicine · 2020Article
- No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus.American journal of physiology. Endocrinology and metabolism · 2019Article
- Erythrocyte glucose-6-phosphate dehydrogenase activity and risk of gestational diabetes.Journal of diabetes and metabolic disorders · 2019Article
- Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3α.Bioscience reports · 2019Article
- Methylation of HIF3A promoter CpG islands contributes to insulin resistance in gestational diabetes mellitus.Molecular genetics & genomic medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
aimsThe aim was to examine associations of insulin resistance and beta cell dysfunction with macrosomia in Chinese women with gestational diabetes mellitus (GDM).
methodsWe performed a secondary analysis of 923 women with GDM enrolled in a randomized controlled trial in 2010-2012 in Tianjin, China. Insulin resistance and beta-cell function were estimated using Homeostasis model assessment. Binary logistic regression was used to obtain adjusted odds ratios (ORs) and 95% confidence intervals (CIs). A two-step adjustment scheme was used to control for effects of potential confounders.
resultsA total of 138 women (16.5%) had excessive weight gain, 127 (7.3%) had macrosomia and 150 (16.3%) had a large for gestational age (LGA) infant. Compared to women in bottom tertile of insulin resistance, women in upper tertile had increased risk of excessive weight gain (OR: 4.32, 95%CI: 1.95-9.62), macrosomia and LGA (OR: 2.61, 95%CI: 1.20-5.69; 2.75, 95%CI: 1.35-5.62, respectively). The observed overall effects were mainly due to their large effect sizes among women with normal pre-pregnancy body weight. However, beta cell function was not found to be associated with either of them.
conclusionsIncreased insulin resistance during pregnancy was associated with excessive weight gain, macrosomia and LGA in Chinese women with GDM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.