ArticleJournal of the American College of Cardiology2018
Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse.
Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
128 citing papers in PubMed, 4 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- Prognostic value of late gadolinium enhancement on cardiac magnetic resonance imaging for non-sustained ventricular tachycardia and sudden cardiac death in hypertrophic cardiomyopathy: a meta-analysis.European radiology · 2026Pooled it
- Echocardiographic assessment of left ventricular mechanics in individuals with mitral valve prolapse: a systematic review and meta-analysis.The international journal of cardiovascular imaging · 2024Pooled it
- The Association Between Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Ventricular Arrhythmia in Patients With Mitral Valve Prolapse: A Systematic Review and Meta-Analysis.Clinical cardiology · 2024Pooled it
- A Systematic Review of 4D-Flow MRI Derived Mitral Regurgitation Quantification Methods.Frontiers in cardiovascular medicine · 2019Pooled it
- Regional strain patterns in patients with mitral valve prolapse.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Myocardial late gadolinium enhancement is strongly associated with ventricular arrhythmias in mitral valve prolapse.The international journal of cardiovascular imaging · 2026Article
- Arrhythmic Mitral Valve Prolapse as a Regional Stretch-Induced Cardiomyopathy with Fibro-Inflammatory Signature: A Conceptual Review.Journal of cardiovascular development and disease · 2026Review
- Ventricular arrhythmia inducibility predicts clinical events in mitral valve prolapse syndrome.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Biatrial Inflammatory and Profibrotic Remodeling in Severe Mitral Regurgitation: A Comparative Tissue and Echocardiographic Study Versus CABG Comparator Group.Diagnostics (Basel, Switzerland) · 2026Article
- Preoperative fragmented QRS as a predictor of postoperative left ventricular systolic dysfunction after isolated mitral valve replacement.BMC cardiovascular disorders · 2026Article
- [Cardiovascular magnetic resonance imaging: routine use in cardiology and unique strengths].Innere Medizin (Heidelberg, Germany) · 2026Review
- Predictors of Left Ventricular Fibrosis in Mitral Annular Disjunction: Cardiac Magnetic Resonance Imaging Study.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Doming Volume in Mitral Valve Prolapse: Pathophysiology, Imaging Implications and Clinical Relevance.Journal of cardiovascular development and disease · 2026Review
- End-stage valvular heart disease requiring heart transplantation: risk profile, surgical modifiers, and myocardial pathology.BMC cardiovascular disorders · 2026Article
- TClinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Article
- The Arrhythmogenic Spectrum of Mitral Valve Disease: Pathophysiology, Risk Stratification, and Surgical Management.Journal of clinical medicine · 2026Review
- Left atrioventricular coupling in isolated pediatric mitral valve prolapse with preserved ejection fraction and moderate regurgitation.Scientific reports · 2026Article
- Staging of Cardiac Adverse Remodeling in Moderate or Severe Aortic Regurgitation.JACC. Cardiovascular imaging · 2025Article
- Collagen Fiber Maturity and Architecture in MVP-Associated Fibrosis Quantified by Digital Pathology.Cells · 2025Article
68 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies reported left ventricular (LV) fibrosis in patients with primary mitral regurgitation (MR) thought to be principally due to mitral valve prolapse (MVP).
objectivesThis study sought to evaluate the prevalence, characteristics, and prognostic implications of LV fibrosis in a large cohort of primary MR patients with and without MVP using cardiovascular magnetic resonance (CMR).
methodsPatients referred for contrast CMR assessment of chronic primary MR were enrolled and underwent comprehensive assessment of cardiac remodeling, severity of MR, and LV replacement fibrosis. Primary MR patients were stratified into: an MVP group if there was >2 mm mitral leaflet displacement on cine-CMR, or a non-MVP group. Patients were followed for arrhythmic events (sudden cardiac death, aborted sudden cardiac arrest, and sustained or inducible ventricular arrhythmia).
resultsA total of 356 primary MR patients (177 MVP and 179 non-MVP) were enrolled. LV fibrosis was more prevalent in the MVP group than the non-MVP group (36.7% vs. 6.7%; p < 0.001). The presence of MVP had the strongest association (odds ratio: 6.82; p < 0.001) with LV fibrosis even after adjustment for clinical variables, measures of cardiac remodeling, and MR severity. During follow-up (median 1,354 days), MVP patients with LV fibrosis had the highest event rate for arrhythmic events.
conclusionsIn primary MR patients, LV fibrosis is more prevalent in MVP than non-MVP, suggesting a unique pathophysiology beyond volume overload in MVP. LV fibrosis in primary MR may represent a risk marker of arrhythmic events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.