ArticlePublic health nutrition2018
Dietary protein and changes in markers of cardiometabolic health across 20 years of follow-up in middle-aged Americans.
Article in Public health nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Plant-based protein consumption patterns among Saudi Generation Z: a cross-sectional study of dietary frequencies, health outcomes, and sustainable eating behaviors.Frontiers in public health · 2026Article
- Association of total, plant, and animal protein intake with hypertension among type 2 diabetic patients in Azar cohort population: A cross-sectional study.Health promotion perspectives · 2025Article
- Association between dietary protein intake and bone mineral density based on NHANES 2011-2018.Scientific reports · 2025Article
- The Effect of Protein Intake on Bone Disease, Kidney Disease, and Sarcopenia: A Systematic Review.Current developments in nutrition · 2025Review
- Regional differences in protein intake and protein sources of Korean older adults and their association with metabolic syndrome using the 2016-2019 Korea National Health and Nutrition Examination Surveys: a cross-sectional study.Korean journal of community nutrition · 2024Article
- Modelling the replacement of red and processed meat with plant-based alternatives and the estimated effect on insulin sensitivity in a cohort of Australian adults.The British journal of nutrition · 2024Article
- Dietary total, plant, and animal protein intake in relation to cardiovascular outcomes and inflammatory factors in elderly men: A cross-sectional study.Food science & nutrition · 2024Article
- Association between protein intake, diet quality, and obesity in Australian adults: a comparison of measurement units.Journal of nutritional science · 2024Article
- Adherence to aerobic training combined with high protein intake is associated with low blood pressure in Italian older adults: a cross-sectional study.Aging clinical and experimental research · 2023Article
- Protein Intake Is Associated with Blood Pressure and Cholesterol Levels in Italian Older Adults: A Cross-Sectional Study.Metabolites · 2023Article
- High Protein Intake at Lunch Is Negatively Associated with Blood Pressure in Community-Dwelling Older Adults: A Cross-Sectional Study.Nutrients · 2023Article
- Plant protein consumption is associated with body mass index among women of reproductive age in Indonesia.Frontiers in nutrition · 2023Article
- Associations of percentage energy intake from total, animal and plant protein with overweight/obesity and underweight among adults in Addis Ababa, Ethiopia.Public health nutrition · 2022Article
- Article
- Association between Protein Intake and the Risk of Hypertension among Chinese Men and Women: A Longitudinal Study.Nutrients · 2022Article
- Macronutrient Intake in Adults Diagnosed with Metabolic Syndrome: Using the Health Examinee (HEXA) Cohort.Nutrients · 2021Article
- Dietary Animal to Plant Protein Ratio Is Associated with Risk Factors of Metabolic Syndrome in Participants of the AHS-2 Calibration Study.Nutrients · 2021Article
- The long-term association of different dietary protein sources with metabolic syndrome.Scientific reports · 2021Article
- The association of animal and plant protein with successful ageing: a combined analysis of MEDIS and ATTICA epidemiological studies.Public health nutrition · 2021Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDietary protein plays a role in counteracting age-related muscle loss. However, limited long-term data exist on protein intake and markers of cardiometabolic health, which tend to deteriorate with age.
designProspective cohort study. FFQ-derived protein intake (g/d) and cardiometabolic markers were assessed up to five times across 20 years. Markers included systolic (SBP) and diastolic (DBP) blood pressures, circulating lipids (total, HDL and LDL cholesterol; TAG), estimated glomerular filtration rate (eGFR), fasting glucose (FG), weight and waist circumference (WC). Mixed models accounting for repeated measures were used to estimate adjusted mean annualized changes in outcomes per quartile category of protein.
settingFramingham Heart Study Offspring cohort, USA. SUBJECTS: Participants (n 3066) with 12 333 unique observations, baseline (mean (sd)) age=54·0 (9·7) years, BMI=27·4 (4·9) kg/m2, 53·5 % female.
resultsIn fully adjusted models, there were favourable associations (mean (se)) of total protein with annualized changes in SBP (lowest v. highest intake: 0·34 (0·06) v. 0·04 (0·06) mmHg, P trend=0·001) and eGFR (-1·03 (0·06) v. -0·87 (0·05) ml/min per 1·73 m2, P trend=0·046), unfavourable associations with changes in FG (0·013 (0·004) v. 0·028 (0·004) mmol/l, P trend=0·004) and no associations with weight, WC, DBP or lipids. Animal protein was favourably associated with SBP and unfavourably with FG and WC; plant protein was favourably associated with FG and WC.
conclusionsThe present study provides evidence that protein intake may influence changes in cardiometabolic health independent of change in weight in healthy adults and that protein's role in cardiometabolic health may depend on the protein source.
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