ArticleGenome biology2018
Optical and physical mapping with local finishing enables megabase-scale resolution of agronomically important regions in the wheat genome.
Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Recent duplications and rare structural variations revealed by comparative sequence analysis of low molecular weight glutenin subunits (LMW-GS) genes re-identified using LMWgsFinder in 26 genomes of the grass family.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Joint linkage and association analysis identifies genomic regions and candidate genes for yield-related traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Recombination and structural variation in a large 8-founder wheat MAGIC population.G3 (Bethesda, Md.) · 2025Article
- Flow Cytometric Analysis and Sorting of Plant Chromosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Flow Sorting-Assisted Optical Mapping.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Fine mapping of hybrid necrosis gene Ne1 in common wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Analysis of Genetic Regions Related to Field Grain Number per Spike From Chinese Wheat Founder Parent Linfen 5064.Frontiers in plant science · 2021Article
- Genetic architecture underpinning yield component traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Article
- Haplotype-Based, Genome-Wide Association Study Reveals Stable Genomic Regions for Grain Yield in CIMMYT Spring Bread Wheat.Frontiers in genetics · 2020Article
- Genome-Wide Expression Profiling of Genes Associated with theInternational journal of molecular sciences · 2019Article
- High-resolution mapping of rachis nodes per rachis, a critical determinant of grain yield components in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Identification of a candidate gene for a QTL for spikelet number per spike on wheat chromosome arm 7AL by high-resolution genetic mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
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42 authors.
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Abstract
backgroundNumerous scaffold-level sequences for wheat are now being released and, in this context, we report on a strategy for improving the overall assembly to a level comparable to that of the human genome.
resultsUsing chromosome 7A of wheat as a model, sequence-finished megabase-scale sections of this chromosome were established by combining a new independent assembly using a bacterial artificial chromosome (BAC)-based physical map, BAC pool paired-end sequencing, chromosome-arm-specific mate-pair sequencing and Bionano optical mapping with the International Wheat Genome Sequencing Consortium RefSeq v1.0 sequence and its underlying raw data. The combined assembly results in 18 super-scaffolds across the chromosome. The value of finished genome regions is demonstrated for two approximately 2.5 Mb regions associated with yield and the grain quality phenotype of fructan carbohydrate grain levels. In addition, the 50 Mb centromere region analysis incorporates cytological data highlighting the importance of non-sequence data in the assembly of this complex genome region.
conclusionsSufficient genome sequence information is shown to now be available for the wheat community to produce sequence-finished releases of each chromosome of the reference genome. The high-level completion identified that an array of seven fructosyl transferase genes underpins grain quality and that yield attributes are affected by five F-box-only-protein-ubiquitin ligase domain and four root-specific lipid transfer domain genes. The completed sequence also includes the centromere.
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