Evidence map›Paper›PMID 30115117›Full record

ArticleAlzheimer's research & therapy2018

IgM response against amyloid-beta in aging: a potential peripheral protective mechanism.

Sudhanshu Agrawal, Edsel M Abud, Shikha Snigdha, Anshu Agrawal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Genetic evidence suggests a protective role of immunoglobulin M in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Dysregulation of Systemic Immunity in Aging and Dementia.Frontiers in cellular neuroscience · 2021
    Review
  15. Immune and Inflammatory Determinants Underlying Alzheimer's Disease Pathology.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Article
  16. Article
  17. Article
  18. Protective Effect of Buyang Huanwu Decoction on Neurovascular Unit in Alzheimer's Disease Cell Model via Inflammation and RAGE/LRP1 Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sudhanshu AgrawalDivision of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Edsel M AbudUCI-MIND, University of California, Irvine, Irvine, CA, 92697, USA.
Shikha SnigdhaUCI-MIND, University of California, Irvine, Irvine, CA, 92697, USA.
Anshu AgrawalDivision of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, USA. aagrawal@uci.edu.ORCID 0000-0002-3323-9152

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Impaired ability of aged human dendritic cells to maintain mucosal toleranceR01AG045216 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGRAWAL, ANSHU · 2014 to 2018
$1.6M
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NIA NIH HHS AG045216NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG16573NIA NIH HHS R01 AG045216UCI-MIND Pilot grant
6 · The paper itself

Abstract

backgroundThe immune system plays a major role in the pathogenesis of age-related dementia, including Alzheimer's disease (AD). An insight into age-associated changes in the immune response to amyloid-beta (Aβ) in individuals without AD may be beneficial in identifying mechanisms preventing accumulation of Aβ.

methodsWe examined the response of human monocyte-derived dendritic cells (DCs), T cells, and peripheral blood mononuclear cells (PBMCs) from healthy aged and young subjects to Aβ peptide 1-42, Aβ fibrils, and recombinant, nonaggregated tau-4 protein with a view to understand the role of peripheral immunity in AD.

resultsOur studies revealed that DCs from healthy aged subjects display weak reactivity towards the Aβ peptide and no reactivity towards Aβ fibrils and tau compared with their young counterparts. An analysis of old and young PBMCs revealed that there is no significant T-cell memory against Aβ peptide, fibrils, or tau. Remarkably, the plasma levels of IgM antibodies specific to Aβ peptide 1-42 were significantly increased in aged subjects compared with young subjects, while IgG levels were comparable. Aβ peptide-specific IgM and IgG levels were also determined in the plasma of AD subjects compared with age-matched controls to demonstrate that the immune response against Aβ is stronger in AD patients. A decline in Aβ peptide-specific IgM antibodies was observed in AD patients compared with age-matched controls. In contrast, the levels of IgG as well as interleukin-21, the major cytokine involved in class switching, were increased in AD and patients with mild cognitive impairment, indicating a strong immune response against Aβ.

conclusionsCollectively, low immunogenicity of Aβ in healthy controls may prevent inflammation while the generation of specific IgM antibodies may help in the clearance of Aβ in healthy subjects.

Indexed as

AdultAgedAged, 80 and overAge FactorsAgingAmyloid beta-PeptidesCells, CulturedCytokinesDendritic CellsFemaleHumansImmunoglobulin MLeukocytes, MononuclearMalePeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)CytokinesImmunoglobulin MPeptide Fragmentstau ProteinsAmyloid betaDendritic cellsHumanIgM antibody

Identifiers

PMID30115117
PMCPMC6097437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.