ArticleCancer imaging : the official publication of the International Cancer Imaging Society2018
Castleman disease versus lymphoma in neck lymph nodes: a comparative study using contrast-enhanced CT.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Hyperenhancing paravertebral mass in an adolescent: A rare presentation of unicentric Castleman disease.Radiology case reports · 2026Article
- Left ovarian mass revealing multivisceral lymphoma.Radiology case reports · 2024Article
- Typical and Atypical Imaging Features of Malignant Lymphoma in the Abdomen and Mimicking Diseases.Journal of the Korean Society of Radiology · 2023Review
- A novel diagnostic tool for hyaline vascular Castleman disease versus lymphoma based on contrast-enhanced computed tomography in neck mass.Journal of the Chinese Medical Association : JCMA · 2022Article
- Comprehensive analysis of 65 patients with Castleman disease in a single center in China.Scientific reports · 2022Article
- Spectrum of [Molecular imaging and biology · 2021Review
- Prognostic value of pretreatment contrast-enhanced computed tomography in esophageal neuroendocrine carcinoma: A multi-center follow-up study.World journal of gastroenterology · 2020Article
- Analysis of Clinical Characteristics, Pathological Changes and Changes of Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Children with Castleman's Disease.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to determine the contrast-enhanced CT characteristics for differentiating between Castleman disease (CD) and lymphoma in neck lymph nodes.
methodsThis retrospective study evaluated the number (solitary or multiple), strength of contrast-enhancement, type of contrast-enhancement, surrounding vessels, contrast-enhanced Hounsfield unit (HU) values, and anatomical distributions of lymph nodes in 34 patients with confirmed CD and 55 patients with newly diagnosed untreated lymphoma. Independent t-tests, receiver operating characteristic (ROC) curve analysis, and chi-square tests were used to evaluate the variables and CT features.
resultsSeveral significant differences were found between CD and lymphoma. The interval between first contrast-enhanced CT and biopsy/surgery was significantly longer in the CD group (mean 72 ± 105 days, median 60 days) than in the lymphoma patients (mean 30 ± 2 days, median 12 days; p = 0.015). The lymphoma patients presented significantly more often with fatigue and fever (p = 0.023 and p = 0.016 respectively) than did the CD subjects. HU values of nodules after enhancement were significantly higher in the CD patients than in the lymphoma patients. In cases involving multiple lymph nodes, in all the CD cases, all affected nodes were located in only the left or right side of the neck, not bilaterally. ROC analysis showed a significant difference in contrast-enhanced CT attenuation values between lymphoma and CD (p < 0.001, area under the curve = 0.954), with a cut-off value of 92.5 HU. We constructed a decision tree according to these imaging characteristics.
conclusionsContrast-enhanced CT can be useful for differentiating between CD and lymphoma.
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