ArticleJournal of neuroengineering and rehabilitation2018
Bilateral reaching deficits after unilateral perinatal ischemic stroke: a population-based case-control study.
Article in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 73 citations in OpenAlex.
- Accuracy deficits during robotic time-constrained reaching are related to altered prefrontal cortex activity in children with cerebral palsy.Journal of neuroengineering and rehabilitation · 2024Trial
- Recent Advances in Sensor-Based Upper-Limb and Hand Exoskeletons for Post-Stroke Rehabilitation: A Technical and Biomedical Review.Sensors (Basel, Switzerland) · 2026Review
- Feasibility study of the assessment of upper limb function in children with Unilateral Cerebral Palsy using an end-effector robotic device.Journal of neuroengineering and rehabilitation · 2026Article
- Non-Linear Modeling of Motor Development in Typically Developing Children and Youth Aged 5-18 Years Using Robot-Based Behavioral Assessments.Bioengineering (Basel, Switzerland) · 2025Article
- Robotic assessment of bilateral and unilateral upper limb functions in adults with cerebral palsy.Journal of neuroengineering and rehabilitation · 2024Article
- Characterization of bilateral reaching development using augmented reality games.Human movement science · 2024Article
- Roles of Handedness and Hemispheric Lateralization: Implications for Rehabilitation of the Central and Peripheral Nervous Systems: A Rapid Review.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2024Review
- Relationship between somatosensory and visuo-perceptual impairments and motor functions in adults with hemiparetic cerebral palsy.Frontiers in neurology · 2024Article
- Spatial mapping of posture-dependent resistance to passive displacement of the hypertonic arm post-stroke.Journal of neuroengineering and rehabilitation · 2023Article
- In-depth quantification of bimanual coordination using the Kinarm exoskeleton robot in children with unilateral cerebral palsy.Journal of neuroengineering and rehabilitation · 2023Article
- High-Frequency Ipsilesional versus Low-Frequency Contralesional Transcranial Magnetic Stimulation after Stroke: Differential Effects on Ipsilesional Upper Extremity Motor Recovery.Medicina (Kaunas, Lithuania) · 2023Article
- Impairments of the ipsilesional upper-extremity in the first 6-months post-stroke.Journal of neuroengineering and rehabilitation · 2023Article
- Article
- Robotic mapping of motor cortex in children with perinatal stroke and hemiparesis.Human brain mapping · 2022Article
- Bihemispheric developmental alterations in basal ganglia volumes following unilateral perinatal stroke.NeuroImage. Clinical · 2022Article
- Robotic devices for paediatric rehabilitation: a review of design features.Biomedical engineering online · 2021Review
- Perinatal stroke: mapping and modulating developmental plasticity.Nature reviews. Neurology · 2021Review
- Relative independence of upper limb position sense and reaching in children with hemiparetic perinatal stroke.Journal of neuroengineering and rehabilitation · 2021Article
- Unimanual and bimanual motor performance in children with developmental coordination disorder (DCD) provide evidence for underlying motor control deficits.Scientific reports · 2021Article
- Robotic assessment of rapid motor decision making in children with perinatal stroke.Journal of neuroengineering and rehabilitation · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDetailed kinematics of motor impairment of the contralesional ("affected") and ipsilesional ("unaffected") limbs in children with hemiparetic cerebral palsy are not well understood. We aimed to 1) quantify the kinematics of reaching in both arms of hemiparetic children with perinatal stroke using a robotic exoskeleton, and 2) assess the correlation of kinematic reaching parameters with clinical motor assessments.
methodsThis prospective, case-control study involved the Alberta Perinatal Stroke Project, a population-based research cohort, and the Foothills Medical Center Stroke Robotics Laboratory in Calgary, Alberta over a four year period. Prospective cases were collected through the Calgary Stroke Program and included term-born children with magnetic resonance imaging confirmed perinatal ischemic stroke and upper extremity deficits. Control participants were recruited from the community. Participants completed a visually guided reaching task in the KINARM robot with each arm separately, with 10 parameters quantifying motor function. Kinematic measures were compared to clinical assessments and stroke type.
resultsFifty children with perinatal ischemic stroke (28 arterial, mean age: 12.5 ± 3.9 years; 22 venous, mean age: 11.5 ± 3.8 years) and upper extremity deficits were compared to healthy controls (n = 147, mean age: 12.7 ± 3.9 years). Perinatal stroke groups demonstrated contralesional motor impairments compared to controls when reaching out (arterial = 10/10, venous = 8/10), and back (arterial = 10/10, venous = 6/10) with largest errors in reaction time, initial direction error, movement length and time. Ipsilesional impairments were also found when reaching out (arterial = 7/10, venous = 1/10) and back (arterial = 6/10). The arterial group performed worse than venous on both contralesional and ipsilesional parameters. Contralesional reaching parameters showed modest correlations with clinical measures in the arterial group.
conclusionsRobotic assessment of reaching behavior can quantify complex, upper limb dysfunction in children with perinatal ischemic stroke. The ipsilesional, "unaffected" limb is often abnormal and may be a target for therapeutic interventions in stroke-induced hemiparetic cerebral palsy.
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