Evidence map›Paper›PMID 30114967›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Sex differences in stroke: Challenges and opportunities.

Cheryl D Bushnell, Seemant Chaturvedi, Kathy R Gage, Paco S Herson, Patricia D Hurn, Monik C Jiménez, Steven J Kittner, Tracy E Madsen, Louise D McCullough, Mollie McDermott and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  3. Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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  12. Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  18. NFAT1Cellular & molecular biology letters · 2026
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheryl D Bushnell1 Wake Forest School of Medicine, Winston Salem, NC, USA.
Seemant Chaturvedi2 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Kathy R Gage3 Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Paco S Herson4 Department of Anesthesiology, University of Colorado, Denver, CO, USA.
Patricia D Hurn5 School of Nursing, University of Michigan, Ann Arbor, MI, USA.
Monik C Jiménez6 Division of Women's Health, Brigham and Women's Hospital, Boston, MA, USA.
Steven J Kittner7 Baltimore Veterans Administration Medical Center and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Tracy E Madsen8 Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Louise D McCullough9 Department of Neurology, University of Texas at Houston, Houston, TX, USA.
Mollie McDermott10 Stroke Program, University of Michigan, Ann Arbor, MI, USA.
Mathew J Reeves11 Department of Epidemiology and Biostatistics, Michigan State University, Lansing, MI, USA.
Tatjana Rundek2 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

Targeting TRPM2 channels to improve synaptic and cognitive function after cerebral ischemiaR01NS092645 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S · 2016 to 2020
$1.7M
Examining Racial Disparities in StrokeK01HL124391 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI JIMENEZ, MONIK CARMEN · 2014 to 2018
$761k
NHLBI NIH HHS K01 HL124391NINDS NIH HHS R01 NS092645
6 · The paper itself

Abstract

Biologic sex influences many variables that are important to brain health in general, and to stroke or cerebral ischemia in particular, such as general health status, cerebrovascular anatomy and function, unique risk factors such as pregnancy and preeclampsia, symptomatology, and therapeutic response. A more complete understanding of the scale and depth of sexual dimorphism in the brain and the role of more general sex-based factors is crucial to reducing the burden of stroke in women and men. This focused review highlights recent findings in stroke, including sex differences in epidemiology, risk factor reduction, comparative use of stroke therapeutics in both sexes, the importance of frailty in women, and the biologic basis for sex differences in stroke. Such findings show tremendous promise for the future of personalized medicine in stroke prevention and treatment.

Indexed as

Sex CharacteristicsStrokeFemaleHumansMaleSexsex differencesstrokewomen

Identifiers

PMID30114967
PMCPMC6282222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.