ArticlePloS one2018
Understanding the dynamics of keratin weakening and hydrolysis by proteases.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- The Impact of Biomass Treatment and Plasticizers on the Properties of Chicken Feather-Based Biodegradable Films.Polymers · 2026Article
- Fermented Gallus gallus foot keratin-bone composites as peptide-mineral concentrate for aquafeed: ratio-dependent proximate compositional data.BMC research notes · 2026Article
- Keratinases: microbial sources, mechanisms, and industrial applications in waste valorization.Frontiers in microbiology · 2026Review
- Proteolytic and non-proteolytic mechanisms of keratin degradation inApplied and environmental microbiology · 2025Article
- Bioconversion of chicken feather waste: optimizing keratinase production by Pseudomonas aeruginosa PA1045 and Alcaligenes faecalis IHB B 6507, characterization and application as organic fertilizers.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Giving Broiler Feathers a Good Fate. Optimization of Chemical Hydrolysis for the Production of a Hydrolysate Rich in Free Amino Acids.ACS omega · 2025Article
- Keratinous bioresources: their generation, microbial degradation, and value enhancement for biotechnological applications.World journal of microbiology & biotechnology · 2025Review
- Advancing Textile Waste Recycling: Challenges and Opportunities Across Polymer and Non-Polymer Fiber Types.Polymers · 2025Review
- Degradation of tannery hide raw trimming hairs using keratinolytic bacteria isolated from tannery effluent-contaminated soil.Archives of microbiology · 2023Article
- Antifungal and Antibiofilm Activity of Riparin III against Dermatophytes.Journal of fungi (Basel, Switzerland) · 2023Article
- Parametrically optimized feather degradation by Bacillus velezensis NCIM 5802 and delineation of keratin hydrolysis by multi-scale analysis for poultry waste management.Scientific reports · 2022Article
- Thermostable bacterial laccase for sustainable dyeing using plant phenols.RSC advances · 2022Article
- Strategies of Recovery and Organic Recycling Used in Textile Waste Management.International journal of environmental research and public health · 2022Review
- Platyphylloside, a potential inhibitor from epicarp ofSaudi journal of biological sciences · 2022Article
- Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.Amino acids · 2022Article
- Novel Feather Degrading Keratinases fromMicroorganisms · 2022Article
- Perspectives on Converting Keratin-Containing Wastes Into Biofertilizers for Sustainable Agriculture.Frontiers in microbiology · 2022Review
- Next-Generation Sequencing Analysis of theGenes · 2021Article
- Comparative Genomics Analysis of Keratin-DegradingMicroorganisms · 2021Article
- Structure, Application, and Biochemistry of Microbial Keratinases.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratin is the structural protein in hair, nails, feathers and horns. Keratin is recalcitrant, highly disulfide bonded and is generally inaccessible to common proteases. Only certain types of proteases, called keratinases, are able to cleave the peptide bonds within the keratin structure. Due to this outstanding activity, keratinases have potential application in industries such as livestock, cosmetics and pharmaceuticals. Yet, the process of enzymatic keratin degradation is poorly understood, affecting the development of industrial enzyme formulations that may require full or only partial modification or weakening. Here we investigate the dynamics of keratin weakening and hydrolysis, showing that the decrease in hair mechanical strength is associated with cuticle removal and damage to the cortex and complete breakdown is dependent on reducing agents. Proteases with keratinolytic activity were selected and applied to hair with degradation examined by mechanical, biochemical and microscopic techniques. The extent of keratin degradation was highly enhanced by the presence of reducing agents, principally sodium thioglycolate, exceeding 90% degradation within 16 h of enzymatic treatment. Application was extended to feathers showing that the findings are relevant to improving the use of keratinases in a variety of industries. Overall, the outcomes provide valuable insights into the keratin degradation process by enzymes for the optimization of cosmetic and pharmaceutical products and for livestock waste recycling among other important applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.