ArticlePLoS neglected tropical diseases2018
Human plague associated with Tibetan sheep originates in marmots.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026Review
- Article
- The complex genomic diversity ofEcology and evolution · 2023Article
- A glance at the gut microbiota and the functional roles of the microbes based on marmot fecal samples.Frontiers in microbiology · 2023Article
- Epidemiological Characteristics of Human and Animal Plague in Yunnan Province, China, 1950 to 2020.Microbiology spectrum · 2022Article
- PlagueKD: a knowledge graph-based plague knowledge database.Database : the journal of biological databases and curation · 2022Article
- Stone AgeProceedings of the National Academy of Sciences of the United States of America · 2022Article
- RemodelingProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene.PLoS neglected tropical diseases · 2021Article
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- Induction of Protective Antiplague Immune Responses by Self-Adjuvanting Bionanoparticles Derived from Engineered Yersinia pestis.Infection and immunity · 2020Article
- Past pandemics and climate variability across the Mediterranean.Euro-Mediterranean journal for environmental integration · 2020Article
- Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague.Acta crystallographica. Section F, Structural biology communications · 2019Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
- Marmots andFrontiers in veterinary science · 2019Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Qinghai-Tibet plateau is a natural plague focus and is the largest such focus in China. In this area, while Marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with Tibetan sheep (78 cases with 47 deaths) have been reported on the Qinghai-Tibet plateau since 1956. All of the index infectious cases had an exposure history of slaughtering or skinning diseased or dead Tibetan sheep. In this study, we sequenced and compared 38 strains of Yersinia pestis isolated from different hosts, including humans, Tibetan sheep, and M. himalayana. Phylogenetic relationships were reconstructed based on genome-wide single-nucleotide polymorphisms identified from our isolates and reference strains. The phylogenetic relationships illustrated in our study, together with the finding that the Tibetan sheep plague clearly lagged behind the M. himalayana plague, and a previous study that identified the Tibetan sheep as a plague reservoir with high susceptibility and moderate sensitivity, indicated that the human plague was transmitted from Tibetan sheep, while the Tibetan sheep plague originated from marmots. Tibetan sheep may encounter this infection by contact with dead rodents or through being bitten by fleas originating from M. himalayana during local epizootics.
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