Evidence map›Paper›PMID 30114215›Full record

ArticlePLoS computational biology2018

Characterising seasonal influenza epidemiology using primary care surveillance data.

Robert C Cope, Joshua V Ross, Monique Chilver, Nigel P Stocks, Lewis Mitchell

Abstract read
In one paragraph

Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert C CopeSchool of Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-2048-858X
Joshua V RossSchool of Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Monique ChilverDiscipline of General Practice, The University of Adelaide, Adelaide, South Australia, Australia.
Nigel P StocksDiscipline of General Practice, The University of Adelaide, Adelaide, South Australia, Australia.
Lewis MitchellSchool of Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0001-8191-1997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the epidemiology of seasonal influenza is critical for healthcare resource allocation and early detection of anomalous seasons. It can be challenging to obtain high-quality data of influenza cases specifically, as clinical presentations with influenza-like symptoms may instead be cases of one of a number of alternate respiratory viruses. We use a new dataset of confirmed influenza virological data from 2011-2016, along with high-quality denominators informing a hierarchical observation process, to model seasonal influenza dynamics in New South Wales, Australia. We use approximate Bayesian computation to estimate parameters in a climate-driven stochastic epidemic model, including the basic reproduction number R0, the proportion of the population susceptible to the circulating strain at the beginning of the season, and the probability an infected individual seeks treatment. We conclude that R0 and initial population susceptibility were strongly related, emphasising the challenges of identifying these parameters. Relatively high R0 values alongside low initial population susceptibility were among the results most consistent with these data. Our results reinforce the importance of distinguishing between R0 and the effective reproduction number (Re) in modelling studies.

Indexed as

Adaptive ImmunityAustraliaBasic Reproduction NumberBayes TheoremDisease OutbreaksHumansInfluenza, HumanModels, TheoreticalPopulation SurveillancePrimary Health CareSeasons

Identifiers

PMID30114215
PMCPMC6112683

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.