ArticleMedicine and science in sports and exercise2019
ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness.
Article in Medicine and science in sports and exercise, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Injuries in Artistic Gymnastics: Etiology, Prevention Strategies, and Multifactorial Perspectives-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Characterizing Musculoskeletal Tissue Mechanics Based on Shear Wave Propagation: A Systematic Review of Current Methods and Reported Measurements.Annals of biomedical engineering · 2022Pooled it
- IsGenes · 2022Pooled it
- Effects of Reduced Training Volume of Nordic Hamstring Exercise on Eccentric Knee Flexor Strength, and Fascicle Length and Stiffness of Biceps Femoris Long Head.Scandinavian journal of medicine & science in sports · 2025Trial
- Immediate efficacy of low-intensity focused ultrasound versus planar ultrasound in patients with myofascial pain syndrome of upper trapezius: a randomized controlled clinical trial.BMC musculoskeletal disorders · 2025Trial
- The effect of manual therapy on gastrocnemius muscle stiffness in healthy individuals.Foot (Edinburgh, Scotland) · 2019Trial
- Changes in Passive Muscle Stiffness Following Biceps Femoris Strain Injury in Track-and-Field Athletes: Cross-Sectional and Longitudinal Analyses.Scandinavian journal of medicine & science in sports · 2026Article
- Genetic Susceptibility to Sport-Related Muscle Injuries: Insights from the Literature and Novel Gene Candidates.International journal of molecular sciences · 2025Review
- The influences of genetic polymorphisms in three candidate genes on the athletic performance of Korean athletes.Genes & genomics · 2025Article
- Exploring the Association BetweenGenes · 2025Article
- Relationship Between Thiopurine S-Methyltransferase Genotype and Phenotype in Pediatric Acute Lymphoblastic Leukemia in Addis Ababa, Ethiopia.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Pelvic Asymmetry and Stiffness of the Muscles Stabilizing the Lumbo-Pelvic-Hip Complex (LPHC) in Tensiomyography Examination.Journal of clinical medicine · 2025Article
- Article
- Biceps femoris long head stiffens after 2 weeks of training cessation in highly trained sprinters.European journal of applied physiology · 2024Article
- Reliability of MyotonPro in measuring the biomechanical properties of the quadriceps femoris muscle in people with different levels and types of motor preparation.Frontiers in sports and active living · 2024Article
- [Genetics in sports-muscle injuries].Orthopadie (Heidelberg, Germany) · 2023Review
- Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen.Clinical science (London, England : 1979) · 2023Review
- Acute changes in passive stiffness of the individual hamstring muscles induced by resistance exercise: effects of muscle length and exercise duration.European journal of applied physiology · 2023Article
- Review
- Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia.Frontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMuscle injury is the most common sports injury. Muscle stiffness, a risk factor for muscle injury, is lower in females than in males, implying that sex-related genetic polymorphisms influence muscle injury associated with muscle stiffness. The present study aimed to clarify the associations between two genetic polymorphisms (rs2234693 and rs9340799) in the estrogen receptor 1 gene (ESR1) and muscle injury or muscle stiffness.
methodsIn study 1, a questionnaire was used to assess the muscle injury history of 1311 Japanese top-level athletes. In study 2, stiffness of the hamstring muscles was assessed using ultrasound shear wave elastography in 261 physically active young adults. In both studies, rs2234693 C/T and rs9340799 G/A polymorphisms in the ESR1 were analyzed using the TaqMan SNP Genotyping Assay.
resultsIn study 1, genotype frequencies for ESR1 rs2234693 C/T were significantly different between the injured and noninjured groups in a C-allele dominant (CC + CT vs TT: odds ratio, 0.62; 95% confidence interval, 0.43-0.91) and additive (CC vs CT vs TT: odds ratio, 0.70; 95% confidence interval, 0.53-0.91) model in all athletes. In study 2, hamstring muscle stiffness was lower in subjects with the CC + CT genotype than in those with the TT genotype; a significant linear trend (CC < CT < TT) was found (r = 0.135, P = 0.029). In contrast, no associations were observed between ESR1 rs9340799 G/A and muscle injury or stiffness.
conclusionsOur results suggest that the ESR1 rs2234693 C allele, in contrast to the T allele, provides protection against muscle injury by lowering muscle stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.