Evidence map›Paper›PMID 30113229›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018

Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension.

Michael R La Frano, Johannes F Fahrmann, Dmitry Grapov, Theresa L Pedersen, John W Newman, Oliver Fiehn, Mark A Underwood, Karen Mestan, Robin H Steinhorn, Stephen Wedgwood

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Michael R La FranoWest Coast Metabolomics Center, University of California, Davis Genome Center, University of California , Davis, California.ORCID 0000-0002-2269-1688
Johannes F FahrmannWest Coast Metabolomics Center, University of California, Davis Genome Center, University of California , Davis, California.
Dmitry GrapovCreative Data Solutions, Ballwin, Missouri.
Theresa L PedersenObesity and Metabolism Research Unit, United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center , Davis, California.
John W NewmanWest Coast Metabolomics Center, University of California, Davis Genome Center, University of California , Davis, California.
Oliver FiehnWest Coast Metabolomics Center, University of California, Davis Genome Center, University of California , Davis, California.
Mark A UnderwoodDepartment of Pediatrics, University of California, Davis Medical Center , Sacramento, California.
Karen MestanDepartment of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
Robin H SteinhornDepartment of Pediatrics, Children's National Medical Center, George Washington University , Washington, District of Columbia.
Stephen WedgwoodDepartment of Pediatrics, University of California, Davis Medical Center , Sacramento, California.
Agricultural Research Service · USUniversity of California Davis Medical Center · USCalifornia Polytechnic State University · USChildren's National · USKing Abdulaziz University · SANorthwestern University · USThe University of Texas MD Anderson Cancer Center · US

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
Oxidant Stress and Gene Polymorphisms in Bronchopulmonary DysplasiaK23HL093302 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI MESTAN, KAREN K · 2010 to 2013
$538k
Metabolomics: an accurate mass GC-DART AccuTOF mass spectrometer for routine idenS10RR031630 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2011 to 2011
$260k
NCRR NIH HHS S10 RR031630NHLBI NIH HHS K23 HL093302NIDDK NIH HHS U24 DK097154
6 · The paper itself

Abstract

Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia (BPD) and remains a primary contributor to increased morbidity and mortality among preterm infants. Unfortunately, at the present time, there are no reliable early predictive markers for BPD-associated PH. Considering its health consequences, understanding in utero perturbations that lead to the development of BPD and BPD-associated PH and identifying early predictive markers is of utmost importance. As part of the discovery phase, we applied a multiplatform metabolomics approach consisting of untargeted and targeted methodologies to screen for metabolic perturbations in umbilical cord blood (UCB) plasma from preterm infants that did ( n = 21; cases) or did not ( n = 21; controls) develop subsequent PH. A total of 1,656 features were detected, of which 407 were annotated by metabolite structures. PH-associated metabolic perturbations were characterized by reductions in major choline-containing phospholipids, such as phosphatidylcholines and sphingomyelins, indicating altered lipid metabolism. The reduction in UCB abundances of major choline-containing phospholipids was confirmed in an independent validation cohort consisting of UCB plasmas from 10 cases and 10 controls matched for gestational age and BPD status. Subanalyses in the discovery cohort indicated that elevations in the oxylipins PGE1, PGE2, PGF2a, 9- and 13-HOTE, 9- and 13-HODE, and 9- and 13-KODE were positively associated with BPD presence and severity. This expansive evaluation of cord blood plasma identifies compounds reflecting dyslipidemia and suggests altered metabolite provision associated with metabolic immaturity that differentiate subjects, both by BPD severity and PH development.

Indexed as

BiomarkersBronchopulmonary DysplasiaDyslipidemiasFemaleFetal BloodGestational AgeHumansHypertension, PulmonaryInfant, NewbornInfant, PrematureLipid MetabolismMaleMetabolomicsBiomarkersbronchopulmonary dysplasialipidsmetabolomicsoxylipinspulmonary hypertension

Identifiers

PMID30113229
PMCPMC6295510
OpenAlexW2887994638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.