ArticleHuman brain mapping2018
Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Go with the (Blood) Flow: A Systematic Review on the Relationship Between Dynamic Functional Connectivity and Information Processing Speed.Neuropsychology review · 2026Pooled it
- Altered functional connectivity is associated with Repeatable Battery for the Assessment of Neuropsychological Status across the dementia spectrum.Journal of the International Neuropsychological Society : JINS · 2026Article
- Spatial-Temporal Characteristics of Brain Activity in Autism Spectrum Disorder Based on Hidden Markov Model and Dynamic Graph Theory: A Resting-State fMRI Study.Brain sciences · 2024Article
- Reconfiguration of Brain Network Dynamics in Autism Spectrum Disorder Based on Hidden Markov Model.Frontiers in human neuroscience · 2022Article
- Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Neuroimaging in Psychiatry and Neurodevelopment: why the emperor has no clothes.The British journal of radiology · 2019Review
- Generalizability and reproducibility of functional connectivity in autism.Molecular autism · 2019Article
- Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.Human brain mapping · 2018Article
- Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.JAMA network open · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Synchrony of brain activity over time describes the functional connectivity between brain regions but does not address the temporal component of this relationship. We propose a complementary method of analysis by introducing the width of cross-correlation curves between functional MRI (fMRI) time series as a metric of the relative duration of synchronous activity between brain regions, or "sustained connectivity". Using resting-state fMRI, cognitive, and demographics data from 1,003 subjects included in the Human Connectome Project, we find that sustained connectivity is a reproducible trait in individuals, heritable, more transient in females, and shows changes with age in early adulthood. Sustained connectivity in sensory brain regions is specifically associated with differences in processing speed across subjects, particularly in men. In contrast, traditional functional connectivity was correlated with a measure of episodic memory, but not with processing speed. Individual differences in hemodynamic response function (HRF) are closely approximated by sustained connectivity and width of the HRF is also correlated with processing speed across individuals, suggesting that variability in hemodynamic response may be influenced by transient versus sustained neural activity rather than simply differences in vascularity and signal transduction. Sustained connectivity may provide new opportunities to study brain dynamics in clinical populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.