ArticleHuman brain mapping2018
Modulation of network-to-network connectivity via spike-timing-dependent noninvasive brain stimulation.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Stimuli, presentation modality, and load-specific brain activity patterns during n-back task.Human brain mapping · 2019Pooled it
- Frontoparietal paired associative stimulation versus single-site stimulation for generalized anxiety disorder: a pilot rTMS study.Journal of psychiatry & neuroscience : JPNTrial
- Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs.Brain sciences · 2026Review
- Exploring cortical excitability modulation to promote cognitive resilience in aging: an rTMS study protocol.Frontiers in human neuroscience · 2026Article
- Causal evidence for dorsal stream involvement in object shape recognition: A tractography-guided ccPAS Registered Report study.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Precision Network Modeling of Transcranial Magnetic Stimulation Across Individuals Suggests Therapeutic Targets and Potential for Improvement.Human brain mapping · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Precision Network Modeling of Transcranial Magnetic Stimulation Across Individuals Suggests Therapeutic Targets and Potential for Improvement.medRxiv : the preprint server for health sciences · 2024Article
- Alterations in large-scale resting-state network nodes following transcranial focused ultrasound of deep brain structures.Frontiers in human neuroscience · 2024Article
- Recent Research Progress on the Use of Transcranial Magnetic Stimulation in the Treatment of Vascular Cognitive Impairment.Neuropsychiatric disease and treatment · 2024Review
- Article
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- Targeted neuroplasticity in spatiotemporally patterned invasive neuromodulation therapies for improving clinical outcomes.Frontiers in neuroinformatics · 2023Article
- Strength-dependent perturbation of whole-brain model working in different regimes reveals the role of fluctuations in brain dynamics.PLoS computational biology · 2022Article
- Gradual enhancement of corticomotor excitability during cortico-cortical paired associative stimulation.Scientific reports · 2022Article
- Paired associative stimulation applied to the cortex can increase resting-state functional connectivity: A proof of principle study.Neuroscience letters · 2022Article
- Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study.Neural plasticity · 2022Article
- Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study.Frontiers in human neuroscience · 2022Article
- Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities.EBioMedicine · 2021Review
- Network-level macroscale structural connectivity predicts propagation of transcranial magnetic stimulation.NeuroImage · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Human cognitive abilities and behavior are linked to functional coupling of many brain regions organized in distinct networks. Gaining insights on the role those networks' dynamics play in cognition and pathology requires their selective, reliable, and reversible manipulation. Here we document the possibility to manipulate the interplay between two brain networks in a controlled manner, by means of a Transcranial Magnetic Stimulation (TMS) protocol inducing spike timing dependent plasticity (STDP). Pairs of TMS pulses at specific inter-stimulus intervals, repeatedly delivered over two negatively correlated nodes of the default mode network (DMN) and the task-positive network (TPN) defined on the basis of individual functional magnetic resonance imaging (fMRI) data, induced a modulation of network-to-network connectivity, even reversing correlation from negative to slightly positive in 30% of cases. Results also suggest a baseline-dependent effect, with a greater connectivity modulation observed in participants with weaker between-networks connectivity strength right before TMS. Finally, modulation of task-evoked fMRI activity patterns during a sustained attention task was also observed after stimulation, with a faster or slower switch between rest and task blocks according to the timing of TMS pulses. The present findings promote paired associative TMS as a promising technique for controlled manipulation of fMRI connectivity dynamics in humans, as well as the causal investigation of brain-behavior relations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.