Evidence map›Paper›PMID 30113068›Full record

ArticlePhotochemistry and photobiology2019

S,S-Chiral Linker Induced U Shape with a Syn-facial Sensitizer and Photocleavable Ethene Group.

Goutam Ghosh, Sarah J Belh, Callistus Chiemezie, Niluksha Walalawela, Ashwini A Ghogare, Mariana Vignoni, Andrés H Thomas, Sherri A McFarland, Edyta M Greer, Alexander Greer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Goutam GhoshDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.
Sarah J BelhDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.
Callistus ChiemezieDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.
Niluksha WalalawelaDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.
Ashwini A GhogareDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.
Mariana VignoniINIFTA, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT La Plata-CONICET, La Plata, Argentina.
Andrés H ThomasINIFTA, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT La Plata-CONICET, La Plata, Argentina.ORCID 0000-0002-8054-7799
Sherri A McFarlandDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.ORCID 0000-0002-8028-5055
Edyta M GreerDepartment of Natural Sciences, Baruch College of the City University of New York, New York, NY.
Alexander GreerDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.ORCID 0000-0003-4444-9099

Funding

Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapyR01CA222227 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI GUJAR, SHASHI, MCFARLAND, SHERRI · 2018 to 2022
$2.6M
Acadia UniversityAgencia de Promoción Científica y TecnológicaBeatrice Hunter Cancer Research InstituteConsejo Nacional de Investigaciones Cientıficas y Tecnicas (CONICET)Eugene Lang Foundation at Baruch CollegeInnovation TrustNational Science Foundation ACI01053575National Science Foundation CHE-1464975Natural Sciences and Engineering Council of CanadaNatural Sciences and Engineering Council of CanadaNCI NIH HHS R01 CA222227Petroleum Research Fundthe Canadian Foundation for Innovationthe Canadian Institutes of Health Researchthe Nova Scotia ResearchUniversity of North Carolina at Greensboro
6 · The paper itself

Abstract

There is a major need for light-activated materials for the release of sensitizers and drugs. Considering the success of chiral columns for the separation of enantiomer drugs, we synthesized an S,S-chiral linker system covalently attached to silica with a sensitizer ethene near the silica surface. First, the silica surface was modified to be aromatic rich, by replacing 70% of the surface groups with (3-phenoxypropyl)silane. We then synthesized a 3-component conjugate [chlorin sensitizer, S,S-chiral cyclohexane and ethene building blocks] in 5 steps with a 13% yield, and covalently bound the conjugate to the (3-phenoxypropyl)silane-coated silica surface. We hypothesized that the chiral linker would increase exposure of the ethene site for enhanced

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyDrug LiberationEthylenesPhotosensitizing AgentsProton Magnetic Resonance SpectroscopyStereoisomerismethyleneEthylenesPhotosensitizing Agents

Identifiers

PMID30113068
PMCPMC6347524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.