ReviewEuropean journal of clinical investigation2018
Cancer and dementia: Two sides of the same coin?
Review in European journal of clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- The risk of dementia in breast cancer survivors: a meta-analysis of observational studies.Annals of medicine · 2025Pooled it
- Androgen deprivation therapy for prostate cancer and neurocognitive disorders: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2024Pooled it
- Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges.Pharmacology & therapeutics · 2020Pooled it
- Linking dementia prodromes and cancer through motor function impairment: the Rotterdam-Study.BMC geriatrics · 2026Article
- Dueling diagnosis of cancer and cognitive impairment: exploring the association of cognitive impairment with survival using the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Differentiation Between Early and Severe Stages of Dementia in Claims Data Based on Diagnosis, Prescription, and Utilization Patterns.Neurology and therapy · 2025Article
- Review
- Post-diagnosis smoking habit change and incident dementia in cancer survivors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association of cancer history with structural brain aging markers of Alzheimer's disease and related dementias risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Increased microglia activation in late non-central nervous system cancer survivors links to chronic systemic symptomatology.Human brain mapping · 2023Article
- Article
- Association between cancer and dementia risk in the UK Biobank: evidence of diagnostic bias.European journal of epidemiology · 2023Article
- Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment.Cancers · 2023Article
- Review
- Caregivers with Cancer Patients: Focus on Hispanics.Cancers · 2023Review
- The Role of Dementia Diagnostic Delay in the Inverse Cancer-Dementia Association.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Evaluation of mild cognitive impairment and dementia in patients with metastatic renal cell carcinoma.Journal of geriatric oncology · 2022Article
- Right at Home: Living with Dementia and Multimorbidities.Ageing and society · 2022Article
- Characteristics and Outcome Determinants of Hospitalized Older Patients with Cognitive Dysfunction.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noncentral nervous system cancer and the brain share an interesting and complex relation, with an emerging body of evidence showing that cancer patients are at an increased risk of developing cognitive problems. In contrast, population-based studies consistently find an inverse link between cancer and dementia, that is patients with dementia having a lower risk of subsequently developing cancer, and cancer patients being less often diagnosed with dementia. Different biological processes such as inversely activated cell proliferation and survival pathways have been suggested to have an important role underlying this inverse association. However, the effect of methodological biases including surveillance or survival bias has not been completely ruled out, calling into question the inverse direction of the association between cancer and dementia. In fact, emerging evidence now suggests that cancer and dementia might share a positive association. This narrative review summarises the current literature on cancer, cognitive problems and dementia. Moreover, different strategies will be discussed to reduce the impact of potential methodological biases on the association between cancer and dementia, trying to reveal the true direction of this link.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.