ArticleEJNMMI research2018
In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET.
Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Messenger RNA delivery of a dual CD25/CD122 affinity-tuned IL-2 variant prolongs exposure and potentiates antitumor T cell immunity.Science advances · 2026Article
- mRNA vaccine designs for optimal adjuvanticity and delivery.RNA biology · 2024Review
- Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion.Photoacoustics · 2023Article
- FDG-PET/CT in the Monitoring of Lymphoma Immunotherapy Response: Current Status and Future Prospects.Cancers · 2023Review
- Article
- Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination.Turkish journal of medical sciences · 2022Observational
- Absolute Lymphocyte Count After COVID-19 Vaccination Is Associated with Vaccine-Induced Hypermetabolic Lymph Nodes onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Smart Lipid-Based Nanosystems for Therapeutic Immune Induction against Cancers: Perspectives and Outlooks.Pharmaceutics · 2021Review
- Imaging Assessment of Tumor Response in the Era of Immunotherapy.Diagnostics (Basel, Switzerland) · 2021Review
- Review
- Early Evaluation of Immunotherapy Response in Lymphoma Patients by 18F-FDG PET/CT: A Literature Overview.Journal of personalized medicine · 2021Review
- Quantitative DynamicCancers · 2021Article
- Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA.EJNMMI research · 2021Article
- Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines.Pharmaceutics · 2021Review
- Article
- Positron Emission Tomography-Based Response to Target and Immunotherapies in Oncology.Medicina (Kaunas, Lithuania) · 2020Review
- Dexamethasone premedication suppresses vaccine-induced immune responses against cancer.Oncoimmunology · 2020Article
- Immunotherapy by Immune Checkpoint Inhibitors and Nuclear Medicine Imaging: Current and Future Applications.Cancers · 2020Review
- Can benign lymphoid tissue changes inCancer immunology, immunotherapy : CII · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
background[
resultsWe observed exclusive increase of glucose uptake in spleen compared to other organs thanks to liposome-mediated RNA targeting to this immune-relevant organ. In vivo and ex vivo FDG uptake analysis in the spleen of vaccinated mice correlated well with antigen-specific T cell activation. Moreover, the use of an irrelevant (antigen non-specific) RNA also resulted in enhanced FDG uptake early after vaccination through the activation of several other splenic cell populations. The glucose uptake was also dependent on the dose of RNA administered in line with the activation and frequencies of proliferating antigen-specific T cells as well as the general activation pattern of splenic cell populations.
conclusionsOur preclinical results show rapid and transient vaccination-induced increase of FDG uptake within the spleen reflecting immune activation preceding T cell proliferation. FDG-PET/CT in patients is also capable to image this immune activation resulting in a new potential application of FDG-PET/CT to image immune processes in new immunological therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.