ReviewCurrent treatment options in oncology2018
Prognostic Factors of Extramammary Paget's Disease.
Review in Current treatment options in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Diagnostic Algorithm for Secondary Extramammary Paget Disease from Institutional Cases and Literature Review.Cancers · 2025Article
- Rare Localization of Extramammary Paget's Disease in the Axilla: A Case Report and Literature Review.Journal of clinical medicine · 2025Article
- Repair of Scrotal Wounds after Extensive Excision of Extramammary Paget Disease with Thick Split-thickness Skin Graft.Plastic and reconstructive surgery. Global open · 2024Article
- The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease.Frontiers in immunology · 2024Article
- Outcomes and prognostic factors of surgically treated extramammary Paget's disease of the vulva.Journal of gynecologic oncology · 2023Article
- The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget's Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre.Journal of clinical medicine · 2023Article
- A primer on extramammary Paget's disease for the urologist.Translational andrology and urology · 2020Review
- Response to Pyrotinib in a Chinese Patient with Bone-Metastatic Scrotal Paget's Disease Harboring Triple Uncommon HER2 Mutation: A Case Report.OncoTargets and therapy · 2020Article
- Identification of Predictive Factors for Post-operative Recurrence and Clinical Outcomes of Primary Vulvar Extramammary Paget Disease.In vivo (Athens, Greece)Review
- Survival and Treatment Patterns in Vulvar Paget's Disease: Evidence From SEER.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementMost patients with extramammary Paget's disease (EMPD) show a good prognosis; however, some patients develop fatal metastases. Early detection is important for improving prognosis, due to the difficulties associated with the treatment of distant EMPD metastases. Several studies have emphasized the importance of the invasion level of the primary lesion for predicting the presence of metastasis, and deeper invasion or increased thickness is correlated with poorer prognosis. Vascular tumor invasion of the primary lesion can also predict the risk of metastasis. Lymph node metastasis is a strong indicator for poor prognosis, and the number of lymph node metastases affects patient outcome, in that there is a significant difference in survival between patients with zero or one lymph node metastasis and those with more than two lymph node metastases. Serum markers may be able to predict the presence of systemic metastases, and carcinoembryonic antigen and cytokeratin 19 fragment 21-1 reflect disease progression and may be clinically valuable. Although several genetic alterations have been determined for EMPD, factors determining prognosis should be further explored.
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