ReviewReviews in endocrine & metabolic disorders2018
Transgender medicine - puberty suppression.
Review in Reviews in endocrine & metabolic disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 55 citations in OpenAlex.
- Experience of a Gender Identity Unit in Spain (2015-2023): Trends, Treatments, Surgeries, and Detransitions.Archives of sexual behavior · 2026Article
- Gender Reassignment and the Role of the Laboratory in Monitoring Gender-Affirming Hormone Therapy.Journal of clinical medicine · 2024Review
- Shifts in Gender-Related Medical Requests by Transgender and Gender-Diverse Adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023Article
- Managing Dermatologic Effects of Gender-Affirming Therapy in Transgender Adolescents.Adolescent health, medicine and therapeutics · 2022Review
- Gender incongruence and gender dysphoria in childhood and adolescence-current insights in diagnostics, management, and follow-up.European journal of pediatrics · 2021Review
- Routine Screening for Transgender and Gender Diverse Adults Taking Gender-Affirming Hormone Therapy: a Narrative Review.Journal of general internal medicine · 2021Review
- Considerations in genetic counseling of transgender patients: Cultural competencies and altered disease risk profiles.Journal of genetic counseling · 2021Article
- Article
- The effect of early puberty suppression on treatment options and outcomes in transgender patients.Nature reviews. Urology · 2020Review
- Current approach to the clinical care of adolescents with gender dysphoria.Acta bio-medica : Atenei Parmensis · 2020Review
- Bone Health in the Transgender Population.Clinical reviews in bone and mineral metabolism · 2019Article
- Health considerations for transgender women and remaining unknowns: a narrative review.Therapeutic advances in endocrinology and metabolism · 2019Review
- Gender dysphoria and transgender medicine in the year 2018.Reviews in endocrine & metabolic disorders · 2018Article
- Emerging topics in transgender medicine.Reviews in endocrine & metabolic disorders · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty suppression is the reversible first step of endocrine medical treatment in transgender youth, and allows for two very important aspects of transgender management. Firstly, it buys the patient, family and their medical team time to fully evaluate the presence and persistence of gender dysphoria. Secondly, it successfully prevents the development of cis-gender unwanted secondary sexual characteristics. The latter, when present, almost certainly increase the burden of psychological co-morbidity for any transgender person. This management is modelled from treatment of gonadotropin-dependent precious puberty, with use of GnRH agonists at its core. With the increasing number of transgender youth treated, and the changing demographics of patients seeking medical care, providers are faced with the decision to start puberty blockade at younger ages than previous decades. This article will review the rationale behind puberty blockade for transgender children, the providers' options for achieving this goal, the emerging literature for potential adverse effects on such an approach, as well as identify directions of potential future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.