ReviewContemporary clinical trials communications2018
Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: A review.
Review in Contemporary clinical trials communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05885880 (Evaluating the Effectiveness of Blue-Button Automated Clinical Trial Prescreening on Regional Enrollment), which is not on this map. Cited by 510 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Effectiveness of Blue-Button Automated Clinical Trial Prescreening on Regional Enrollment: a Randomized Trial
Who cites it
510 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Promoting Positive Parenting Skills: A Systematic Review of Interventions.Clinical child psychology and psychiatry · 2026Pooled it
- Pooled it
- Social determinants of health in studies using PROMs to assess toxicities associated with immune checkpoint inhibitor treatment: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study.BMJ (Clinical research ed.) · 2025Pooled it
- Spine-specific robots may offer superior screw placement accuracy in spinal surgery procedures. A systematic review and network and proportional meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Does adopting a healthy diet improve periodontal parameters in patients susceptible to periodontal disease? A systematic review.Evidence-based dentistry · 2025Pooled it
- Improving Participant Recruitment in Clinical Trials: Comparative Analysis of Innovative Digital Platforms.Journal of medical Internet research · 2024Pooled it
- Adaptive designs in clinical trials: a systematic review-part I.BMC medical research methodology · 2024Pooled it
- Improving diversity in research: Successes and limitations of research team education in fostering inclusive recruitment practices and community voice.Accountability in research · 2026Trial
- Trial
- Trial
- A Real-Life Digital Intervention for Personalized Nutrition in Adults With Overweight or Obesity: Remote Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- BRIDGe recruitment strategies for frail older adults in intervention trials: lessons learned from the ACTIVE-AGE@home trial.BMC medical research methodology · 2025Trial
- Success and cost-effectiveness of strategies to recruit older adults to a behavioral intervention research study.Contemporary clinical trials · 2025Trial
- ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers.Translational psychiatry · 2025Trial
- Effect of Famotidine on Outcomes in Pulmonary Arterial Hypertension: A Randomized Controlled Trial.Chest · 2025Trial
- Effects of a non-standard information leaflet on patient recruitment in acute care: Embedded cluster-randomised controlled trial.PloS one · 2025Trial
- Mindfulness-based (non-contact) boxing therapy (MBBT) for depression and anxiety: A feasibility study.PloS one · 2025Trial
- Challenges and Approaches to Recruitment for and Retention in a Dyad-Focused eHealth Intervention During COVID-19: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Patient engagement in protocol development for rare disease clinical trials: a framework.Research involvement and engagement · 2026Article
450 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical trials are time consuming, expensive, and often burdensome on patients. Clinical trials can fail for many reasons. This survey reviews many of these reasons and offers insights on opportunities for improving the likelihood of creating and executing successful clinical trials. Literature from the past 30 years was reviewed for relevant data. Common patterns in reported successful trials are identified, including factors regarding the study site, study coordinator/investigator, and the effects on participating patients. Specific instances where artificial intelligence can help improve clinical trials are identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.