ArticleBladder cancer (Amsterdam, Netherlands)2018
Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome.
Article in Bladder cancer (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition.International journal of clinical oncology · 2023Guideline
- Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition.International journal of clinical oncology · 2020Guideline
- Incidence of non-colorectal/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study.EClinicalMedicine · 2025Article
- Complete response to pembrolizumab in mismatch repair-deficient urothelial carcinoma with local recurrence and recurrent upper tract urothelial carcinoma: a case report.International cancer conference journal · 2025Article
- Review
- Predictive tissue markers in testicular germ cell tumors: Immunohistochemical expression of MLH1 and REV-7 proteins.International urology and nephrology · 2024Article
- Association of a novel frameshift variant and a known deleterious variant in MMR genes with Lynch syndrome in Chinese families.World journal of surgical oncology · 2024Article
- Gender-specific counselling of patients with upper tract urothelial carcinoma and Lynch syndrome.World journal of urology · 2023Review
- Systematic review of reported association studies of monogenic genes and bladder cancer risk and confirmation analysis in a large population cohort.BJUI compass · 2023Review
- Clinicopathological characteristics, molecular landscape, and biomarker landscape for predicting the efficacy of PD-1/PD-L1 inhibitors in Chinese population with mismatch repair deficient urothelial carcinoma: a real-world study.Frontiers in immunology · 2023Article
- Somatic hits in mismatch repair genes in colorectal cancer among non-seminoma testicular cancer survivors.British journal of cancer · 2022Article
- Case Report: Potential Predictive Value of MMR/MSI Status and PD-1 Expression in Immunotherapy for Urothelial Carcinoma.Pathology oncology research : POR · 2022Article
- Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome.World journal of clinical oncology · 2021Article
- Lynch Syndrome: Its Impact on Urothelial Carcinoma.International journal of molecular sciences · 2021Review
- Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets.Communications biology · 2020Article
- Application Areas of Traditional Molecular Genetic Methods and NGS in relation to Hereditary Urological Cancer Diagnosis.Journal of oncology · 2020Review
- A Novel Splice-Site Mutation inFrontiers in oncology · 2020Article
- Genomic characterization for familial cases with urothelial carcinoma.International cancer conference journal · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome. However, growing body of evidence links Lynch syndrome to urological cancers.
objectiveThis review aims to clarify the type of urological malignancies that fall under the Lynch-associated cancer spectrum.
methodsUsing PRISMA guidelines, a systematic search between January 1990 to February 2018, was conducted using the MEDLINE database with the application of the following MESH terms: colorectal neoplasms, hereditary nonpolyposis; DNA mismatch repair; urologic neoplasms; kidney pelvis; ureteral neoplasms; urinary bladder; carcinoma, transitional cell; prostatic neoplasms; testicular neoplasms.
resultsUpper tract urothelial cancers are well established under the Lynch spectrum. Increasing evidence supports its association with prostate cancer. However, there is, inconclusive and limited evidence for an association with bladder and testicular cancer.
conclusionsThe evidence underpinning certain urological malignancies associated with Lynch syndrome has expanded in recent years. Our review may assist in providing a summary of the current standing in literature. However, we recommend further investigations to better clarify associations, particularly with prostate, bladder and testicular cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.