Evidence map›Paper›PMID 30112425›Full record

ArticleBio-protocol2018

Measurement of TLR4 and CD14 Receptor Endocytosis Using Flow Cytometry.

Michael S Schappe, Bimal N Desai

Open access · greenAbstract read
In one paragraph

Article in Bio-protocol, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Efferocytosis requires periphagosomal CaNature communications · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael S SchappePharmacology Department, University of Virginia, Charlottesville, VA, USA.
Bimal N DesaiPharmacology Department, University of Virginia, Charlottesville, VA, USA.
Carter Center · USUniversity of Virginia · US

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0M
TRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2M
TRPM7 at the Crossroads of Tissue Homeostasis and inflammationR01GM108989 · NIGMS · UNIVERSITY OF VIRGINIA · PI DESAI, BIMAL N. · 2016 to 2024
$3.3M
NHLBI NIH HHS P01 HL120840NIGMS NIH HHS R01 GM108989NIGMS NIH HHS T32 GM007055
6 · The paper itself

Abstract

After recognizing extracellular bacterial lipopolysaccharide (LPS), the toll-like receptor 4 (TLR4)-CD14 signaling complex initiates two distinct signaling pathways-one from the plasma membrane and the other from the signaling endosomes (Kagan

Indexed as

BMDMCD14EndocytosisInnate immunityLPSMacrophageTLRTLR4Toll-like receptor

Identifiers

PMID30112425
PMCPMC6089531
OpenAlexW2884684823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.