ReviewBioMed research international2018
Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies.
Review in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Reliable assessment of bone marrow and bone marrow concentrates using automated hematology analyzer.Regenerative medicine · 2019Trial
- Efficient blood cell classification from microscopic smear images using U-Net segmentation and a lightweight CNN.Scientific reports · 2025Article
- The combined effects of extended feeding with a high level of Arthrospira platensis and a commercial enzyme mix or porcine pancreatin on broilers' blood cells, plasma metabolites and liver lipid profile.BMC veterinary research · 2025Article
- Impact of high Spirulina diet, extruded or supplemented with enzymes, on blood cells, systemic metabolites, and hepatic lipid and mineral profiles of broiler chickens.Frontiers in veterinary science · 2024Article
- Inflammatory response in confirmed non-diabetic foot and ankle infections: A case series with normal inflammatory markers.World journal of orthopedics · 2023Article
- Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges.Pharmaceutics · 2023Review
- Autologous Protein Solution processing alters lymphoid and myeloid cell populations and modulates gene expression dependent on cell type.Arthritis research & therapy · 2022Article
- Engineering the multiscale complexity of vascular networks.Nature reviews. Materials · 2022Review
- Potential Mechanism of Action of Current Point-of-Care Autologous Therapy Treatments for Osteoarthritis of the Knee-A Narrative Review.International journal of molecular sciences · 2021Review
- The Use of Autologous Protein Solution (Pro-StrideVeterinary medicine (Auckland, N.Z.) · 2021Article
- Improved Classification of White Blood Cells with the Generative Adversarial Network and Deep Convolutional Neural Network.Computational intelligence and neuroscience · 2020Article
- Mineral-Coated Microparticles Enhance mRNA-Based Transfection of Human Bone Marrow Cells.Molecular therapy. Nucleic acids · 2019Article
- Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration.Frontiers in cardiovascular medicine · 2019Review
- Toxicity Evaluation ofBioMed research international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory. Misconceptions in the practice of biologic orthopedics result in the simplified principle that platelets deliver growth factors, WBCs cause inflammation, and the singular value of bone marrow is the stem cells. The aim of this review is to address these common misconceptions which will enable better development of future orthopedic medical devices. WBC behavior is adaptive in nature and, depending on their environment, WBCs can hinder or induce healing. Successful tissue repair occurs when platelets arrive at a wound site, degranulate, and release growth factors and cytokines which, in turn, recruit WBCs to the damaged tissue. Therefore, a key role of even pure platelet-rich plasma is to recruit WBCs to a wound. Bone marrow contains a complex mixture of vascular cells, white blood cells present at much greater concentrations than in blood, and a small number of progenitor cells and stem cells. The negative results observed for WBC-containing autologous therapies
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.