ArticleBioMed research international2018
Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- The Enigmatic Interplay of Interleukin-10 in the Synergy of HIV Infection Comorbid with Preeclampsia.International journal of molecular sciences · 2024Review
- Association between nitric oxide synthase 3 genetic variant and acute kidney injury following pediatric cardiac surgery.American heart journal · 2022Article
- Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine.The pharmacogenomics journal · 2020Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to analyze the possible association between known genetic risks and preeclampsia in a Han Chinese population.
methodsA total of 156 patients with preeclampsia and 286 healthy Han Chinese women were enrolled and genotyped for 27 genetic alleles associated with preeclampsia in different populations. The association between the genotypes of the individual alleles and preeclampsia and the possible interaction among the alleles were analyzed. Finally logistic models were trained with the genotypes of possible alleles contributing to preeclampsia.
resultsSeven alleles were significantly or marginally significantly associated with preeclampsia, which involved six genes (rs4762 in
conclusionsThe genetic factors were closely associated with preeclampsia in the Han Chinese population despite large ethnicity heterogeneity. The genotypes of different alleles also had synergetic interactions.
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