ArticleNeuroImage. Clinical2018
Modulating functional connectivity after stroke with neurofeedback: Effect on motor deficits in a controlled cross-over study.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07237412 (Neurofeedback-based Visual Restoration Therapy), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurofeedback-based Visual Restoration Therapy
Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
- Towards Network-Based Neurofeedback of Visual Areas to Enhance Visual Perception.Brain topography · 2026Trial
- Self-modulation of motor cortex activity after stroke: a randomized controlled trial.Brain : a journal of neurology · 2022Trial
- Predicting upper extremity motor improvement following therapy using EEG-based connectivity in chronic stroke.NeuroRehabilitation · 2022Trial
- Novel gait training alters functional brain connectivity during walking in chronic stroke patients: a randomized controlled pilot trial.Journal of neuroengineering and rehabilitation · 2019Trial
- Task-Dependent Performance of Wearable Multimodal Biofeedback in Physical Rehabilitation: A Longitudinal Post-Stroke Case Study.Healthcare (Basel, Switzerland) · 2026Article
- Effectiveness of intelligent robotic-assisted training system combined with repetitive facilitative exercise on upper limb motor function after stroke: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2025Article
- Neural correlates of fatigue after traumatic brain injury.Brain communications · 2025Article
- Decoding lower-limb kinematic parameters during pedaling tasks using deep learning approaches and EEG.Medical & biological engineering & computing · 2024Article
- EEG-based sensorimotor neurofeedback for motor neurorehabilitation in children and adults: A scoping review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- EEG decoding with spatiotemporal convolutional neural network for visualization and closed-loop control of sensorimotor activities: A simultaneous EEG-fMRI study.Human brain mapping · 2024Article
- Neural correlates of motor learning: Network communication versus local oscillations.Network neuroscience (Cambridge, Mass.) · 2024Article
- Challenges of neural interfaces for stroke motor rehabilitation.Frontiers in human neuroscience · 2023Article
- Altered directional functional connectivity underlies post-stroke cognitive recovery.Brain communications · 2023Article
- Neurofeedback therapy to improve cognitive function in patients with chronic post-stroke attention deficits: a within-subjects comparison.Frontiers in human neuroscience · 2023Article
- Robotic Biofeedback for Post-Stroke Gait Rehabilitation: A Scoping Review.Sensors (Basel, Switzerland) · 2022Article
- Effective Connectivity in Spinal Cord Injury-Induced Neuropathic Pain.Sensors (Basel, Switzerland) · 2022Article
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Disruption of large-scale electrophysiological networks in stroke patients with visuospatial neglect.Network neuroscience (Cambridge, Mass.) · 2022Article
- Sharpening Working Memory With Real-Time Electrophysiological Brain Signals: Which Neurofeedback Paradigms Work?Frontiers in aging neuroscience · 2022Review
- Toward an Adapted Neurofeedback for Post-stroke Motor Rehabilitation: State of the Art and Perspectives.Frontiers in human neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synchronization of neural activity as measured with functional connectivity (FC) is increasingly used to study the neural basis of brain disease and to develop new treatment targets. However, solid evidence for a causal role of FC in disease and therapy is lacking. Here, we manipulated FC of the ipsilesional primary motor cortex in ten chronic human stroke patients through brain-computer interface technology with visual neurofeedback. We conducted a double-blind controlled crossover study to test whether manipulation of FC through neurofeedback had a behavioral effect on motor performance. Patients succeeded in increasing FC in the motor cortex. This led to improvement in motor function that was significantly greater than during neurofeedback training of a control brain area and proportional to the degree of FC enhancement. This result provides evidence that FC has a causal role in neurological function and that it can be effectively targeted with therapy.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.