Evidence map›Paper›PMID 30112250›Full record

ArticleTranslational vision science & technology2018

In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography.

Qihua Le, Daniel Cordova, Jianjiang Xu, Sophie X Deng

Abstract read
In one paragraph

Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Characterization of the external limbus on corneoscleral topography with ultrawide-field optical coherence tomography.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Limbal stem cell diseases.Experimental eye research · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qihua LeStein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Daniel CordovaStein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jianjiang XuDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China.
Sophie X DengStein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Funding

Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
NEI NIH HHS R01 EY021797
6 · The paper itself

Abstract

purposesTo investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population.

methodsSixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian group) were included in this comparative cross-sectional study. The central cornea and the superior, inferior, nasal, and temporal limbal regions of each subject underwent Fourier-domain AS-OCT. The following parameters were measured: corneal epithelial thickness (CET), maximum limbal epithelial thickness (LET), the mean LET, the width of limbus, distance between scleral spur and the location where limbal epithelium was the thickest (S-T), and limbal epithelial area between scleral spur and the end of Bowman's layer (LEA).

resultsCET was similar in both groups (

conclusionsThe limbal structures can be visualized using AS-OCT and differ significantly between the Caucasian and Chinese eyes. TRANSLATIONAL RELEVANCE: Research of the limbus and surgeons performing procedures involving the limbal area should take into consideration of the anatomic differences especially when limbus is used as an anatomic reference.

Indexed as

anterior segment optical coherence tomographylimbal epitheliumlimbal stem cell deficiencylimbal stem cellslimbus

Identifiers

PMID30112250
PMCPMC6082326

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.