Evidence map›Paper›PMID 30112163›Full record

ArticleInternational journal of endocrine oncology2018

68-Gallium DOTATATE scanning in symptomatic patients with negative anatomic imaging but suspected neuroendocrine tumor.

Jasmine Shell, Xavier M Keutgen, Corina Millo, Naris Nilubol, Dhaval Patel, Samira Sadowski, Myriem Boufraqech, Lily Yang, Roxanne Merkel, Christine Atallah and 2 more

Abstract read
In one paragraph

Article in International journal of endocrine oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Growth hormone-releasing hormone, growth hormone, and neuroendocrine tumors.Journal of clinical & translational endocrinology · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Predictors and Outcomes of Minimally Invasive Surgery for Small Bowel Neuroendocrine Tumors : Minimally Invasive Surgery for SBNETs.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022
    Article
  6. Review
  7. Management Impact ofNuclear medicine and molecular imaging · 2021
    Article
  8. Multiple endocrine neoplasia 1: a broad overview.Therapeutic advances in chronic disease · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jasmine ShellEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Xavier M KeutgenEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Corina MilloPositron Emission Department, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA.
Naris NilubolEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Dhaval PatelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Samira SadowskiEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Myriem BoufraqechEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Lily YangEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Roxanne MerkelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Christine AtallahEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Peter HerscovitchEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Electron KebebewEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Therapeutic targets and novel anticancer agents for endocrine cancersZIABC011286 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NILUBOL, NARIS · 2010 to 2025
$16.6M
Project 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI ODORISIO, THOMAS · 2015 to 2021
$13.2M
NCI NIH HHS P50 CA174521
6 · The paper itself

Abstract

aimThe study's aim was to determine the utility of 68-Gallium DOTATATE positron emission tomography (PET)-CT scanning in patients with carcinoid-like symptoms and negative anatomical imaging.

methodsRetrospective analysis of 22 of 196 patients with carcinoid-like symptoms and no evidence of primary neuroendocrine tumor (NET) based on anatomical imaging and endoscopy who underwent 68-Gallium DOTATATE PET-CT as part of a prospective clinical trial.

resultsOf the biochemically positive patients (n = 11), 18% (n = 2) had additional evidence of NETs based on 68-Gallium DOTATATE PET-CT. Of the patients identified by 68-Gallium DOTATATE PET-CT, 50% (n = 1) had a treatment change and 100% showed symptom improvement. Of the biochemically negative patients (n = 11), 68-Gallium DOTATATE PET-CT identified NETs in 64% (n = 7). Change in management occurred in 71% patients, and 57% of patients showed symptom improvement.

conclusion68-Gallium DOTATATE PET-CT imaging is useful in detecting NETs in symptomatic patients with negative anatomical imaging and changes the treatments in these patients.

Indexed as

68-Gallium DOTATATEbiochemistrycarcinoidneuroendocrine tumorsymptoms

Identifiers

PMID30112163
PMCPMC6085594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.