Evidence map›Paper›PMID 30112005›Full record

ArticleInternational journal of rheumatology2018

Gum Arabic Fibers Decreased Inflammatory Markers and Disease Severity Score among Rheumatoid Arthritis Patients, Phase II Trial.

Ebtihal Kamal, Lamis AbdelGadir Kaddam, Maha Dahawi, Montaser Osman, Mohammed Abdelraman Salih, Alnour Alagib, Amal Saeed

3 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in International journal of rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02804581 phase2unknown statusnot on this map

Potential Role of Gum Arabic as Immunomodulator In Sudanese Rheumatoid Arthritis Patients

TypeinterventionalSponsorLamis KaddamRan2016 to 2016Enrolled45ConditionsRheumatoid ArthritisArmsGum Arabic
NCT04191213 phase2 / phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

Efficacy of Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients : A Randomized, Double-blind, Two-armed Parallel-group, Placebo-controlled Phase II/III Study - Khartoum, Sudan

TypeinterventionalSponsorAl-Neelain UniversityRan2020 to 2020Enrolled100ConditionsSickle Cell Anemia in ChildrenArmsAcacia Senegal extract, Pectin
NCT04381871 phase2 / phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

Phase II ,III Randomized Double Blind Parallel Arms Clinical Trial of Potential Role of Gum Arabic ( Acacia Senegal) as Immunomodulatory Agent Among COVID 19 Patients in Sudan

TypeinterventionalSponsorAl-Neelain UniversityRan2020 to 2020Enrolled110ConditionsCOVID 19ArmsAcacia Senegal, Pectin
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  12. Therapeutic Potential of Gum Arabic (Journal of clinical medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ebtihal KamalDepartment of Microbiology and Immunology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Lamis AbdelGadir KaddamDepartment of Physiology, Faculty of Medicine, Alneelain University Khartoum, Khartoum, Sudan.ORCID 0000-0002-1083-4514
Maha DahawiDepartment of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Montaser OsmanDepartment of Clinical Immunology, Sudan Medical Specialization Board, Khartoum, Sudan.
Mohammed Abdelraman SalihDepartment of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Alnour AlagibDepartment of Rheumatology, Military Hospital, Khartoum, Sudan.
Amal SaeedDepartment of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
University of Khartoum · SDAl-Neelain University · SDSudan Medical Specialization Board · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is autoimmune inflammatory disease that attacks the synovium of the joints. Both TNF PATIENTS AND

methodsThis is clinical trial phase II in which 40 patients were enrolled aged 18 to 70 years. Patients received 30g/day GA for 12 weeks. TNF

resultsThis study showed significant decrease in level of serum TNF

conclusionGum Arabic has favorable immune modulator effect on rheumatoid arthritis. It can be utilized in clinical practice as adjuvant therapy.

trial registrationThis trial was registered with ClinicalTrials.gov Identifier: NCT02804581 Registered at 19 June 2016, prospective registration.

Identifiers

PMID30112005
PMCPMC6077585
OpenAlexW2835395866

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.