Evidence map›Paper›PMID 30111887›Full record

ArticleScientific reports2018

Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet.

Kuang-Yao Cheng, Zhi-Hua Lin, Yu-Pin Cheng, Hsien-Yi Chiu, Nai-Lun Yeh, Tung-Kung Wu, Jong-Shinn Wu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 155 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kuang-Yao ChengDepartment of Mechanical Engineering, National Chiao Tung University, 1001 Ta-Hsueh Road, Hsinchu, 300, Taiwan.
Zhi-Hua LinDepartment of Mechanical Engineering, National Chiao Tung University, 1001 Ta-Hsueh Road, Hsinchu, 300, Taiwan.
Yu-Pin ChengDepartment of Biological Science and Technology, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu, 300, Taiwan.
Hsien-Yi ChiuDepartment of Dermatology, National Taiwan University Hospital Hsinchu Branch, 25 Jingguo Road Section 1 Lane 442, Hsinchu, 300, Taiwan.
Nai-Lun YehDepartment of Family Medicine, National Taiwan University Hospital Hsinchu Branch, 25 Jingguo Road Section 1 Lane 442, Hsinchu, 300, Taiwan.
Tung-Kung WuDepartment of Biological Science and Technology, National Chiao Tung University, 75 Bo-Ai Street, Hsinchu, 300, Taiwan.ORCID 0000-0002-6478-7768
Jong-Shinn WuDepartment of Mechanical Engineering, National Chiao Tung University, 1001 Ta-Hsueh Road, Hsinchu, 300, Taiwan. chongsin@faculty.nctu.edu.tw.ORCID 0000-0003-3764-9690
National Yang Ming Chiao Tung University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we used an argon-based round atmospheric-pressure plasma jet (APPJ) for enhancing wound healing in streptozotocin (STZ) induced diabetic rats. The APPJ was characterized by optical emission spectroscopy. We induced Type 1 and Type 2 diabetes in rats with different amounts of STZ combined with normal and high-fat diets, respectively. The wound area ratio of all the plasma-treated normal and diabetic groups was greatly reduced (up to 30%) compared with that of the untreated groups during healing. Histological analysis revealed faster re-epithelialization, collagen deposition, less inflammation, and a complete skin structure in the plasma-treated groups was found as compared with the untreated control groups. In addition, the new blood vessels of plasma-treated tissues decreased more than untreated tissues in the middle (Day 14) and late (Day 21) stages of wound healing. The plasma-treated wounds demonstrated more transforming growth factor beta (TGF-β) expression in the early stage (Day 7), whereas they decreased in the middle and late stages of wound healing. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) increased after plasma treatment. In addition, plasma-treated water had a higher concentration of hydrogen peroxide, nitrite and nitrate when the plasma treatment time was longer. In summary, the proposed argon APPJ based on the current study could be a potential tool for treating diabetic wounds.

Indexed as

AnimalsArgonAtmospheric PressureCatalaseDiabetes Mellitus, ExperimentalDisease Models, AnimalGlutathione PeroxidaseMalePlasma GasesRatsRats, Sprague-DawleySkinStreptozocinSuperoxide DismutaseTransforming Growth Factor betaWound HealingArgonCatalaseGlutathione PeroxidasePlasma GasesStreptozocinSuperoxide DismutaseTransforming Growth Factor beta

Identifiers

PMID30111887
PMCPMC6093903
OpenAlexW2887147563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.