ArticleScientific reports2018
Opioids prevent regeneration in adult mammals through inhibition of ROS production.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Regenerative repair is connected to early and specific structural, immune, and metabolic MSC signatures in adult mammals.Scientific reports · 2026Article
- Cellular and molecular roles of reactive oxygen species in wound healing.Communications biology · 2024Review
- A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration.NPJ Regenerative medicine · 2024Article
- REDOX Balance in Oligodendrocytes Is Important for Zebrafish Visual System Regeneration.Antioxidants (Basel, Switzerland) · 2023Article
- Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration.Nature communications · 2023Article
- Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study.Bone reports · 2022Review
- Reciprocal Regulation of Shh Trafficking and HAntioxidants (Basel, Switzerland) · 2022Article
- Pain sensing neurons promote tissue regeneration in adult mice.NPJ Regenerative medicine · 2021Article
- Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis.NPJ Regenerative medicine · 2021Article
- Tissue Regeneration: The Dark Side of Opioids.International journal of molecular sciences · 2021Review
- The engine initiating tissue regeneration: does a common mechanism exist during evolution?Cell regeneration (London, England) · 2021Review
- Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis.eLife · 2021Article
- Adipose-Derived Mesenchymal Stromal Cells in Regenerative Medicine: State of Play, Current Clinical Trials, and Future Prospects.Advances in wound care · 2021Review
- Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice.Frontiers in immunology · 2019Article
- Hydrogen Peroxide and Redox Regulation of Developments.Antioxidants (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibition of regeneration and induction of tissue fibrosis are classic outcomes of tissue repair in adult mammals. Here, using a newly developed model of regeneration in adult mammals i.e. regeneration after massive resection of an inguinal fat pad, we demonstrate that both endogenous and exogenous opioids prevent tissue regeneration in adults, by inhibiting the early production of reactive oxygen species (ROS) that generally occurs after lesion and is required for regeneration. These effects can be overcome and regeneration induced by the use of an opioid antagonist. The results obtained in both our new model and the gold standard adult zebrafish demonstrate that this mechanism can be considered as a general paradigm in vertebrates. This work clearly demonstrates that ROS is required for tissue regeneration in adult mammals and shows the deleterious effect of opioids on tissue regeneration through the control of this ROS production. It thus raises questions about opioid-based analgesia in perioperative care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.