ArticleHypertension research : official journal of the Japanese Society of Hypertension2018
Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Computational Ligand-Binding Site Prediction.Advances in experimental medicine and biology · 2026Review
- Mechanistic insights into the synergistic vasodilatory actions of eupatorin, sinensetin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in ex vivo aortic ring model and their antihypertensive efficacy in in vivo rat model.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- In Vivo Antihypertensive and Ex Vivo Vasodilatory Studies of Taxifolin.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Biologically Active Compounds of Malaysian Medicinal and Aromatic Plants.Progress in the chemistry of organic natural products · 2025Review
- Investigation of synergistic interaction of sinensetin, eupatorin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in vasodilation efficacy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Sinensetin Inhibits Angiogenesis in Lung Adenocarcinoma via the miR-374c-5p/VEGF-A/VEGFR-2/AKT Axis.Cell biochemistry and biophysics · 2024Article
- The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension.Frontiers in cardiovascular medicine · 2024Review
- Article
- Flavonoids as Modulators of Potassium Channels.International journal of molecular sciences · 2023Review
- Comparison between Traditional Chinese Medicine Constitution and Blood Biochemical Markers Associated with Left and Right Mammary Hyperplasia in Rural Areas of Southwest China.Journal of healthcare engineering · 2022Article
- Exploration of Lamiaceae in Cardio Vascular Diseases and Functional Foods: Medicine as Food and Food as Medicine.Frontiers in pharmacology · 2022Review
- Therapeutic Effectiveness of Sinensetin Against Cancer and Other Human Complications: A Review of Biological Potential and Pharmacological Activities.Cardiovascular & hematological disorders drug targets · 2022Article
- A New Strategy to Investigate the Efficacy Markers Underlying the Medicinal Potentials ofFrontiers in pharmacology · 2021Article
- Vasorelaxant-Mediated Antihypertensive Effect of the Leaf Aqueous Extract fromBioMed research international · 2021Article
- Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity.Frontiers in pharmacology · 2020Review
- A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases.Frontiers in pharmacology · 2020Review
- Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of KToxicology letters · 2019Article
- Mechanism of vasorelaxation induced by 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in the rats aortic ring assay.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthosiphon stamineus Benth. (Lambiaceae) is an important traditional plant for the treatment of hypertension. Previous studies have demonstrated that the sinensetin content in O. stamineus is correlated with its vasorelaxant activity. However, there is still very little information regarding the vasorelaxant effect of sinensetin due to a lack of scientific studies. Therefore, the present study was designed to investigate the underlying mechanism of action of sinensetin in vasorelaxation using an in vitro precontraction aortic ring assay. The changes in the tension of the aortic ring preparations were recorded using a force-displacement transducer and the PowerLab system. The mechanisms of the vasorelaxant effect of sinensetin were determined in the presence of antagonists. Sinensetin caused relaxation of the aortic ring precontracted with PE in the presence and absence of the endothelium and with potassium chloride in endothelium-intact aortic rings. In the presence of Nω-nitro-L-arginine methyl ester (nitric oxide synthase inhibitor), methylene blue (cyclic guanosine monophosphate lowering agent), ODQ (selective soluble guanylate cyclase inhibitor), indomethacin (a nonselective cyclooxygenase inhibitor), tetraethylammonium (nonselective calcium activator K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.