ArticleScientific reports2018
Identification of Urine Metabolites as Biomarkers of Early Lyme Disease.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- From forest floor to doctor's office: the immunological journey ofFrontiers in immunology · 2026Review
- Temporal metabolomic fingerprinting identifies adenine as a novel biomarker for early detection of Escherichia coli infection in broiler chickens.Scientific reports · 2025Article
- Comparison of the Serodiagnostic Accuracy Tests for Lyme Disease in Adults and Children: A Network Meta-Analysis.Pathogens (Basel, Switzerland) · 2025Review
- UHPLC-MS/MS-based untargeted metabolite profiling of Lyme neuroborreliosis.Scientific reports · 2025Article
- Insights From Omics in Lyme Disease.The Journal of infectious diseases · 2024Review
- Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites.PLoS neglected tropical diseases · 2023Article
- Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii.Parasites & vectors · 2022Article
- Biomarker selection and a prospective metabolite-based machine learning diagnostic for lyme disease.Scientific reports · 2022Article
- Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Laboratory Diagnosis of Lyme Borreliosis.Clinical microbiology reviews · 2021Review
- Recent Progress in Lyme Disease and Remaining Challenges.Frontiers in medicine · 2021Review
- Host Metabolic Response in Early Lyme Disease.Journal of proteome research · 2020Article
- NMR metabolome of Borrelia burgdorferi in vitro and in vivo in mice.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. In this study, metabolomics approaches were applied to evaluate small molecule metabolites in urine from patients with ELD (n = 14), infectious mononucleosis (n = 14) and healthy controls (n = 14). Metabolic biosignatures for ELD versus healthy controls and ELD versus infectious mononucleosis were generated using untargeted metabolomics. Pathway analyses and metabolite identification revealed the dysregulation of several metabolic processes in ELD as compared to healthy controls or mononucleosis, including metabolism of tryptophan. Linear discriminant analyses demonstrated that individual metabolic biosignatures can correctly discriminate ELD from the other patient groups with accuracies of 71 to 100%. These data provide proof-of-concept for use of urine metabolites as biomarkers for diagnostic classification of ELD.
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