ArticleScientific reports2018
Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Exploration of efficacy and mechanism of 0.05% cyclosporine eye drops (II) monotherapy in allergic conjunctivitis-associated dry eye.Eye (London, England) · 2024Trial
- Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized Clinical Trial.JAMA dermatology · 2020Trial
- From Pathways to Patients in Atopic Dermatitis: Advanced Systemic Therapies.International journal of molecular sciences · 2025Review
- Where eye meets body part 1: uniting allergy pathways in ocular and nasal disease - IgE on the offense.Current opinion in allergy and clinical immunology · 2025Review
- Dupilumab-Associated Adverse Events During Treatment of Allergic Diseases.Clinical reviews in allergy & immunology · 2022Review
- Epithelial barrier dysfunction in ocular allergy.Allergy · 2022Review
- Application of vitamin A palmitate eye gel and nurse value of Watson's theory of caring in children with dry eye after strabismus surgery: a randomized trial.Translational pediatrics · 2021Article
- Is the Conjunctiva a Potential Target for Advanced Therapy Medicinal Products?Pharmaceutics · 2021Review
- Selective IL-13 inhibitors for the treatment of atopic dermatitis.Drugs in context · 2021Review
- Conditioned Medium of Human Amniotic Epithelial Cells Alleviates Experimental Allergic Conjunctivitis Mainly by IL-1ra and IL-10.Frontiers in immunology · 2021Article
- Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis.American journal of ophthalmology case reports · 2020Article
- Why Chain Length of Hyaluronan in Eye Drops Matters.Diagnostics (Basel, Switzerland) · 2020Review
- Therapeutic Potential of Lebrikizumab in the Treatment of Atopic Dermatitis.Journal of asthma and allergy · 2020Review
- Nonsteroid management of residual ocular surface disease on dupilumab (ROSDD).International journal of women's dermatology · 2019Article
- Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells.Experimental eye research · 2019Article
- Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants.PloS one · 2019Article
- Biomarkers of ocular allergy and dry eye disease.Romanian journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In the eye, goblet cells responsible for secreting mucins are found in the conjunctiva. When mucin production is not tightly regulated several ocular surface disorders may occur. In this study, the effect of the T helper (Th) 2-type cytokines IL4, IL5, and IL13 on conjunctival goblet cell function was explored. Goblet cells from rat conjunctiva were cultured and characterized. The presence of cytokine receptors was confirmed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Changes in intracellular [Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.