Evidence map›Paper›PMID 30111822›Full record

Observational studyScientific reports2018

Changes in the gut microbiota composition during pregnancy in patients with gestational diabetes mellitus (GDM).

Ilario Ferrocino, Valentina Ponzo, Roberto Gambino, Adriana Zarovska, Filomena Leone, Clara Monzeglio, Ilaria Goitre, Rosalba Rosato, Angelo Romano, Giorgio Grassi and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 7 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ilario FerrocinoDepartment of Agricultural, Forest and Food Sciences, University of Turin, Turin, Italy.ORCID 0000-0002-1657-0054
Valentina PonzoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Roberto GambinoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Adriana ZarovskaDepartment of Medical Sciences, University of Turin, Turin, Italy.
Filomena LeoneClinical Nutrition Unit, S. Anna Hospital, Città della Salute e della Scienza, Turin, Italy.
Clara MonzeglioGynecology and Obstetrics Unit, S. Anna Hospital, Città della Salute e della Scienza, Turin, Italy.
Ilaria GoitreDepartment of Medical Sciences, University of Turin, Turin, Italy.
Rosalba RosatoDepartment of Psychology, University of Turin, Turin, Italy.
Angelo RomanoSC Controllo Alimenti e Igiene delle Produzioni, Istituto Zooprofilattico Sperimentale PVL, Turin, Italy.
Giorgio GrassiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Fabio BroglioDepartment of Medical Sciences, University of Turin, Turin, Italy.
Maurizio CassaderDepartment of Medical Sciences, University of Turin, Turin, Italy.
Luca CocolinDepartment of Agricultural, Forest and Food Sciences, University of Turin, Turin, Italy. lucasimone.cocolin@unito.it.ORCID 0000-0003-4799-7074
Simona BoDepartment of Medical Sciences, University of Turin, Turin, Italy. simona.bo@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM), a common pregnancy complication, is associated with an increased risk of maternal/perinatal outcomes. We performed a prospective observational explorative study in 41 GDM patients to evaluate their microbiota changes during pregnancy and the associations between the gut microbiota and variations in nutrient intakes, anthropometric and laboratory variables. GDM patients routinely received nutritional recommendations according to guidelines. The fecal microbiota (by 16S amplicon-based sequencing), was assessed at enrolment (24-28 weeks) and at 38 weeks of gestational age. At the study end, the microbiota α-diversity significantly increased (P < 0.001), with increase of Firmicutes and reduction of Bacteroidetes and Actinobacteria. Patients who were adherent to the dietary recommendations showed a better metabolic and inflammatory pattern at the study-end and a significant decrease in Bacteroides. In multiple regression models, Faecalibacterium was significantly associated with fasting glucose; Collinsella (directly) and Blautia (inversely) with insulin, and with Homeostasis-Model Assessment Insulin-Resistance, while Sutterella with C-reactive protein levels. Consistent with this latter association, the predicted metagenomes showed a correlation between those taxa and inferred KEGG genes associated with lipopolysaccharide biosynthesis. A higher bacterial richness and strong correlations between pro-inflammatory taxa and metabolic/inflammatory variables were detected in GDM patients across pregnancy. Collectively these findings suggest that the development of strategies to modulate the gut microbiota might be a potentially useful tool to impact on maternal metabolic health.

Indexed as

AdultBlood GlucoseBody Mass IndexDiabetes, GestationalDietFastingFecesFemaleGastrointestinal MicrobiomeHumansInsulin ResistanceMicrobiotaPregnancyPregnancy ComplicationsProspective StudiesRNA, Ribosomal, 16SBlood GlucoseRNA, Ribosomal, 16S

Identifiers

PMID30111822
PMCPMC6093919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.