ArticleScientific reports2018
Genetic relatedness of Staphylococcus aureus isolates obtained from cystic fibrosis patients at a tertiary academic hospital in Pretoria, South Africa.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- ComK2 represses competence development for natural transformation in Staphylococcus aureus grown under strong oxygen limitation.Communications biology · 2025Article
- Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Genetic Diversity and Virulence Profile of Methicillin and Inducible Clindamycin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- A 6-Year Update on the Diversity of Methicillin-ResistantFrontiers in microbiology · 2022Review
- Human-Associated Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Molecular characterisation of methicillin-resistantEpidemiology and infection · 2020Article
- Prevalence and Detection ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2020Article
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Authors and funding
5 authors.
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Abstract
Cystic fibrosis (CF) is an inherited recessive disease that affects mucocillary clearance in the lung, allowing it to be colonised with bacteria such as Staphylococcus aureus. To survive in the CF lung S. aureus adapts both phenotypically and genotypically, through various mechanisms. In this study, multiple specimens were collected from the participants and were processed routinely and were additionally cultured in chromogenic media. Multiplex PCR assays were employed to detect methicillin resistance and selected virulence and quaternary ammonium compound (qac) genes. Genetic relatedness of the S. aureus was determined using agr, SCCmec and spa typing as well as pulsed field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Thirty-three S. aureus isolates were isolated, of which 51% (17/33) were methicillin resistant S. aureus (MRSA). The virulence and qac genes were more prevalent in MRSA than the methicillin sensitive S. aureus (MSSA) isolates. The PFGE analysis showed nine distinct pulsotypes while MLST showed eight sequence types. All the STs detected in this study, except for ST508 have been previously isolated from CF patients according to the literature. This study showed a genetically diverse S. aureus population with a high prevalence of virulence genes among the MRSA isolates from the CF clinic.
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