ArticleMolecular pharmacology2018
Compensatory Expression of Nur77 and Nurr1 Regulates NF-
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In one paragraph
Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Targeting NR4A1 (Nur77) in Macrophage Polarization: Molecular Mechanisms and Translational Prospects for Cardiac Repair After Myocardial Infarction.International journal of molecular sciences · 2026Review
- Dual-Pathway Astrocyte Failure in Parkinson's Disease: Therapeutic Targeting of Nrf2/TFEB Suppression and cGAS-STING/Ferroptosis Activation.Molecular neurobiology · 2026Review
- Astrocytic dysfunction in Parkinson's disease pathogenesis: focusing on alpha-synuclein.Inflammopharmacology · 2026Review
- The Effect of Metformin on Astrocytes in Parkinson's Disease: Challenges and Opportunities.Molecular neurobiology · 2025Review
- Targeting Inflammation: Cytosporone B Modulates Imatinib-Driven Biochemical Alterations in Rat Heart.International journal of molecular sciences · 2025Article
- Regulation ofInternational journal of molecular sciences · 2025Review
- Controversy and multiple roles of the solitary nucleus receptor Nur77 in disease and physiology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Article
- The Nurr1 ligand indole acetic acid hydrazide loaded onto ZnFe2O4 nanoparticles suppresses proinflammatory gene expressions in SimA9 microglial cells.Scientific reports · 2024Article
- Review
- Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators.Histology and histopathology · 2024Review
- Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression.eLife · 2024Article
- Revisiting Alpha-Synuclein Pathways to Inflammation.International journal of molecular sciences · 2023Review
- The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets.Aging and disease · 2022Review
- Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage.Clinical and translational medicine · 2022Article
- A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection.Frontiers in immunology · 2022Article
- Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction.Molecular therapy. Nucleic acids · 2021Article
- Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation.Translational neurodegeneration · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Katriana A PopichakDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Sean L HammondDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Julie A MorenoDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Maryam F AfzaliDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Donald S BackosDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Richard D SlaydenDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Stephen SafeDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.).
Ronald B TjalkensDepartments of Environmental and Radiological Health Sciences (K.A.P., S.L.H., R.B.T.) and Microbiology, Immunology and Pathology (J.A.M., M.F.A., R.D.S.), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.); and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (S.S.) ron.tjalkens@colostate.edu.
Colorado State University · USTexas A&M University · US
Funding
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MNeuroinflammation and developmental vulnerability to manganese toxicityR01ES021656 · NIEHS · COLORADO STATE UNIVERSITY · PI TJALKENS, RONALD · 2013 to 2022
$4.2MRole of Aryl Hydrocarbon Receptor in Microbiota-Colon Stem Cell InteractionsR01ES025713 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN, JAYARAMAN, ARUL · 2016 to 2020
$2.0MManganese-endotoxin interactions and neuroinflammatory brain injuryF31ES026860 · NIEHS · COLORADO STATE UNIVERSITY · PI POPICHAK, KATRIANA · 2017 to 2018
$56kNCATS NIH HHS UL1 TR001082NIEHS NIH HHS F31 ES026860NIEHS NIH HHS R01 ES021656NIEHS NIH HHS R01 ES025713
Abstract
Inflammatory activation of glial cells promotes loss of dopaminergic neurons in Parkinson disease. The transcription factor nuclear factor κB (NF-
Indexed as
AnimalsApoptosisAstrocytesCell NucleusCytokinesDopaminergic NeuronsGene ExpressionGene Expression RegulationHEK293 CellsHumansInflammationMiceMice, Inbred C57BLMice, TransgenicNeurogliaNF-kappa BCytokinesNF-kappa BNr4a1 protein, mouseNr4a2 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Nuclear Receptor Subfamily 4, Group A, Member 2Tumor Necrosis Factor-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.