ReviewScience translational medicine2018
Finding useful biomarkers for Parkinson's disease.
Abstract readReview
In one paragraph
Review in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
76 citing papers in PubMed.
- Simplified quantification of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Trial
- Microfluidics for protein interaction studies: current methods, challenges, and future perspectives.European biophysics journal : EBJ · 2026Review
- Dysregulation of the Extracellular Matrix in the Synaptic Pathology of Parkinson's Disease: Molecular Mechanisms and Novel Therapeutic Approaches.Life (Basel, Switzerland) · 2026Review
- Accelerating Medicines Partnership® Parkinson's Disease Proteomics: A Comprehensive Resource for Advancing Parkinson's Disease Research.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- RNA networks of lysosomal-related biomarkers in Parkinson's disease and their correlations with freezing of gait-associated genes.Frontiers in genetics · 2026Article
- Integrative multi-omics and network-based machine learning for early diagnosis of Parkinson's disease.PloS one · 2026Article
- Mapping the developmental path for Parkinson's disease therapeutics.NPJ Parkinson's disease · 2025Article
- Platelet mitochondrial complex I and IV activities are not reliable stratification biomarkers in Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Blood α-Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies.Annals of neurology · 2025Article
- Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson's disease.Communications medicine · 2025Article
- Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.NPJ Parkinson's disease · 2025Article
- Toward a biological definition of neuronal and glial synucleinopathies.Nature medicine · 2025Review
- Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson's disease.Brain communications · 2025Article
- Longitudinal associations between cerebrospinal fluid glial activation markers, depression, and dopamine transporter availability in patients with Parkinson's disease.Journal of neurology · 2024Article
- Consensus Guidance for Genetic Counseling in GBA1 Variants: A Focus on Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2024Review
- Discriminating Parkinson's disease patients from healthy controls using nasal respiratory airflow.Communications medicine · 2024Article
- α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies.Research square · 2024Article
- Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease.Nature communications · 2024Article
- Article
- A Comprehensive Review of the Role of Biomarkers in Early Diagnosis of Parkinson's Disease.Cureus · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors.
Alice S Chen-PlotkinDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. chenplot@pennmedicine.upenn.edu.ORCID 0000-0002-3387-2038
Roger AlbinNeurology Service and GRECC, VAAHS, Ann Arbor, MI 48105, USA.
Roy AlcalayDepartment of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
Debra BabcockNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
Vikram BajajVerily/Google Life Sciences, South San Francisco, CA 94080, USA.
Dubois BowmanDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Alex BukoHuman Metabolome Technology-America, Boston, MA 02134, USA.
Jesse CedarbaumBiogen, Cambridge, MA 02142, USA.ORCID 0000-0002-5146-8784
Daniel ChelskyCaprion Biosciences, Montreal, Quebec H2X 3Y7, Canada.ORCID 0000-0002-8126-2525
Mark R CooksonCell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1058-3831
Ted M DawsonInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-6459-0893
Richard DeweyDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6615-5035
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-5549-2212
Mark FrasierThe Michael J. Fox Foundation for Parkinson's Research, New York, NY 10163, USA.ORCID 0000-0002-1730-0603
Dwight GermanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Katrina GwinnNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.ORCID 0000-0002-8277-651X
Xuemei HuangDepartment of Neurology, Penn State University-Hershey Medical Center, Hershey, PA 17033, USA.
Catherine KopilThe Michael J. Fox Foundation for Parkinson's Research, New York, NY 10163, USA.ORCID 0000-0001-8678-7550
Thomas KremerPharmaceutical Research and Early Development, NORD Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
Shirley LaschInstitute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
Ken MarekInstitute for Neurodegenerative Disorders, New Haven, CT 06510, USA.ORCID 0000-0002-4197-5627
Jarrod A MartoDepartments of Cancer Biology and Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Kalpana MerchantChaperone Therapeutics, Portland, OR 97229, USA.ORCID 0000-0003-1118-9403
Brit MollenhauerParacelsus-Elena-Klinik, 34128 Kassel, Germany.
Anna NaitoThe Michael J. Fox Foundation for Parkinson's Research, New York, NY 10163, USA.
Judith PotashkinDepartment of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA.ORCID 0000-0002-8782-3071
Alyssa ReimerThe Michael J. Fox Foundation for Parkinson's Research, New York, NY 10163, USA.ORCID 0000-0002-7023-6145
Liana S RosenthalDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5140-3967
Rachel Saunders-PullmanDepartment of Neurology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY 10003, USA.ORCID 0000-0001-8132-8806
Clemens R ScherzerCenter for Advanced Parkinson's Disease Research and Precision Neurology Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0567-9193
Todd ShererThe Michael J. Fox Foundation for Parkinson's Research, New York, NY 10163, USA.
Andrew SingletonLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Margaret SutherlandNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.ORCID 0000-0002-8262-4110
Ines ThieleLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.ORCID 0000-0002-8071-7110
Marcel van der BrugGenentech, San Francisco, CA 94080, USA.
Kendall Van Keuren-JensenNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
David VaillancourtDepartment of Applied Physiology, Biomedical Engineering, and Neurology, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-5663-6476
David WaltDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Andrew WestDepartment of Neurology, University of Alabama, Birmingham, AL 35233, USA.
Jing ZhangDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
Funding
Understanding Mechanisms of a-synuclein pathologyP50NS038377 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KO, HANSEOK · 1998 to 2019
$38.8MUPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1MPenn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MNINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3MPenn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1MAssessment of Candidate Loci in Neurological diseasesZIAAG000957 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$12.2MPublic Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1MGene expression in the human brainZIAAG000947 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2009 to 2025
$7.2MMechanisms of LRRK2 Mediated NeurotoxicityR01NS064934 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEST, ANDREW B · 2010 to 2025
$6.3MMultimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2MJohns Hopkins Medicine Biomarker Discovery in Parkinson's DiseaseU01NS082133 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M. · 2012 to 2016
$4.1MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NIA NIH HHS P30 AG010124NINDS NIH HHS K02 NS080915NINDS NIH HHS P50 NS038377NINDS NIH HHS P50 NS091856NINDS NIH HHS R01 NS064934NINDS NIH HHS R33 NS097643NINDS NIH HHS R56 NS082941NINDS NIH HHS U01 NS082133NINDS NIH HHS U01 NS082134NINDS NIH HHS U01 NS082148NINDS NIH HHS U01 NS082151NINDS NIH HHS U01 NS094148NINDS NIH HHS U01 NS097028NINDS NIH HHS U01 NS097037NINDS NIH HHS U01 NS097056NINDS NIH HHS U01 NS100603NINDS NIH HHS U24 NS095871
Abstract
The recent advent of an "ecosystem" of shared biofluid sample biorepositories and data sets will focus biomarker efforts in Parkinson's disease, boosting the therapeutic development pipeline and enabling translation with real-world impact.
Indexed as
BiomarkersCohort StudiesDisease ProgressionHumansParkinson DiseaseProdromal SymptomsReference StandardsBiomarkers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.